Limitations of MRI in differentiating solid and cystic components of craniopharyngiomas

Basit Öğe Kaydı
dc.authorid0000-0003-4864-5652
dc.authorid0000-0003-1480-6235
dc.authorid0000-0002-8617-9958
dc.authorid0000-0003-0128-6947
dc.authorid0000-0002-9412-7306
dc.authorid0000-0002-1847-2562
dc.contributor.authorKaraalioğlu, Banu
dc.contributor.authorÇakıcı Öksüz, Nazlı
dc.contributor.authorİpek, Veyselkarani
dc.contributor.authorÇakır, Aslı
dc.contributor.authorKahraman, Osman
dc.contributor.authorÖzbek, Muhammet Arif
dc.date.accessioned2025-09-27T10:51:37Z
dc.date.available2025-09-27T10:51:37Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractPurpose Craniopharyngiomas (CP) present with both solid and cystic structures in magnetic resonance imaging (MRI) stud ies. Contrary to MRI appearance, components described as cysts are not infrequently found as non-fluent structures during surgery. This study aims to address the discrepancy between radiology and surgery regarding the nature of these lesions and to evaluate them for their preoperative predictability. Materials and methods Preoperative MRI images of 24 CP patients were analyzed. The cystic components of the tumors were assessed in terms of quantitative and qualitative signal properties and contrast enhancement on conventional pulse sequences, and analyzed based on their macroscopic appearances. Results Thirteen of 31 lesions (42%) that suggested cyst on MRI were solid during surgery, with none showing contrast uptake. MRI demonstrated 100% sensitivity and negative predictive value (NPV), 71.7% specificity, and 58% positive pre dictive value (PPV) in identifying true cysts. Most lesions resembling cysts were hyperintense on FLAIR and T1WI and isointense on ADC maps, suggesting high protein content. However, surgically confirmed fluid-filled cysts exhibited similar signal characteristics in a comparable proportion. The only significant imaging indicator was a hypointense appearance on T2WI, with a mean intensity ratio close to that of the basal ganglia. Conclusion Accurate identification of solid and cystic components in craniopharyngiomas is critical for effective treatment planning. Although MRI is traditionally considered reliable for this purpose, 42% of lesions that appeared cystic without contrast enhancement were ultimately confirmed as non-fluid or solid during surgery. This study was unable to establish definitive MRI characteristics to reliably differentiate between cystic and solid components. Further research with larger cohorts is warranted to validate potential imaging markers and improve diagnostic accuracy.
dc.identifier.citationKaraalioğlu, B., Çakıcı Öksüz, N., İpek, V., Çakır, A., Kahraman, O., & Özbek, M. A. (2025). Limitations of MRI in differentiating solid and cystic components of craniopharyngiomas. Child's Nervous System, 41(1), pp. 1-11. https://doi.org/10.1007/s00381-025-06941-y
dc.identifier.doi10.1007/s00381-025-06941-y
dc.identifier.endpage11
dc.identifier.issn1433-0350
dc.identifier.issn0256-7040
dc.identifier.issue1
dc.identifier.pmidPMID: 40956448
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s00381-025-06941-y
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1123
dc.identifier.volume41
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÇakıcı Öksüz, Nazlı
dc.institutionauthorid0000-0003-1480-6235
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofChild's Nervous System
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCraniopharyngioma
dc.subjectMagnetic Resonance Imaging
dc.subjectCystic Craniopharyngioma
dc.titleLimitations of MRI in differentiating solid and cystic components of craniopharyngiomas
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text
Boyut:
1.6 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu