Assessment of the ovarian reserve in patients with Beta-thalassemia major; A prospective longitudinal study

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorÖzcan, Aykut
dc.contributor.authorGülseren, Varol
dc.contributor.authorÖzcan, Esin
dc.contributor.authorToz, Emrah
dc.contributor.authorTuran, Volkan
dc.date.accessioned2023-07-03T06:38:32Z
dc.date.available2023-07-03T06:38:32Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractObjective: Repeated blood transfusions in women with Beta-thalassemia major (BTM) may lead to iron overload and increase oxidative stress and consequently resulting in ovarian damage. We aimed to evaluate the alterations in the ovarian reserve of transfusion-dependent BTM patients over a time period of one year and compared the anti-mullerian hormone (AMH) levels between women with BTM and healthy population. Material and methods: This longitudinal prospective study was conducted in 41 women with transfusion-dependent BTM at the tertiary hospital. The hospital database between 1996 to 2021 was screened for women diagnosed with BTM. Anti-mullerian hormone levels were assessed at baseline and one year later. Results: Twenty-five (60.9%) of the patients had amenorrhea while 16 (39.1%) were observed to have normal cycles. The mean AMH values of all women were 2.7±1.8 ng/mL at the initial measurement which was significantly lower compared to age related AMH (mean 4.0±0.4 ng/mL) nomogram of healthy population (P= 0.001). The baseline AMH values of the patients with amenorrhea were found to be lower than the patients with normal menstrual cycles (2.1±1.8 vs 3.6±1.5 ng/mL, P= 0.009). After a one-year follow-up, there was a trend towards to a decrease in AMH levels of the patients with normal menstrual cycles. Conclusion: Serum AMH values is decreased in patients with transfusion-dependent BTM. It would be beneficial to inform all patients about possible effects of repeated blood transfusions on fertility.en_US
dc.identifier.citationÖzcan, A., Gülseren, V., Özcan, E., Toz, E., & Turan, V. (2023). Assessment of the ovarian reserve in patients with Beta-thalassemia major; A prospective longitudinal study. Journal of the Turkish German Gynecology Association, 24(3), pp. 159-164. https://doi.org/10.4274/jtgga.galenos.2023.2022-12-2en_US
dc.identifier.doi10.4274/jtgga.galenos.2023.2022-12-2en_US
dc.identifier.endpage164en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue3en_US
dc.identifier.pmidPMID: 37351586en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.4274/jtgga.galenos.2023.2022-12-2
dc.identifier.urihttps://hdl.handle.net/20.500.13055/483
dc.identifier.volume24en_US
dc.identifier.wosWOS:001085135500004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofJournal of the Turkish German Gynecology Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvarian Reserveen_US
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectBeta Thalassemiaen_US
dc.titleAssessment of the ovarian reserve in patients with Beta-thalassemia major; A prospective longitudinal studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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