Making health out of recycling: The innovative role of hawthorn seed waste in diabetes management

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dc.authorid0000-0001-5611-5235
dc.authorid0000-0002-2370-6415
dc.authorid0000-0002-4810-6352
dc.contributor.authorSavcı, Serap
dc.contributor.authorKocadağ Kocazorbaz, Ebru
dc.contributor.authorMenfaatli, Esra
dc.contributor.authorGündeğer, Ersin
dc.date.accessioned2025-08-27T12:05:11Z
dc.date.available2025-08-27T12:05:11Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalı
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disorder that affects millions of people worldwide, and its prevalence is increasing due to global population growth and lifestyle changes. One of the key strategies in managing DM is the inhibition of enzymes such as α-glucosidase and Dipeptidyl Peptidase-IV (DPP-IV), as well as reducing protein glyca tion. In this study, the antidiabetic potential of Crataegus monogyna (hawthorn) seeds, which are generally considered agricultural waste, was investigated. Hawthorn seeds were extracted using water, ethanol, and methanol as solvents, and the obtained extracts were analyzed for their phytochemical composition, total phenolic and flavonoid content, antioxi dant activity, enzyme inhibitory effects, and antiglycation potential. The methanol extract exhibited the highest phenolic content (53.21±4.69 mg GAE/g) and antioxidant activity, while the ethanol and methanol extracts showed strong anti glycation effects. The water extract demonstrated the highest inhibitory activity against DPP-IV (IC50: 0.21 mg/mL) and α-glucosidase (IC50: 85.23 µg/mL). In silico molecular docking and dynamics simulations revealed that procyanidin A2 and procyanidin B1 exhibited strong binding affinities for DPP-IV and α-glucosidase, respectively, and that these complexes were stable. These results suggest that hawthorn seeds, traditionally considered waste, possess significant pharmacological potential and could offer a new, natural, and sustainable therapeutic option for diabetes management. This study serves as an important example for the valorization of biomass and the repurposing of waste materials in the pharmaceutical field.
dc.description.sponsorshipA part of this study was supported by the TÜBİTAK 2209- A University Students Research Projects Support Program. We would like to thank TÜBİTAK for their valuable support. (Project application no: 1919B012330365) Bu çalışmanın bir kısmı TÜBİTAK 2209-A Üniversite Öğrencileri Araştırma Projeleri Destekleme Programı kapsamında desteklenmiştir. Değerli destekleri için TÜBİTAK'a teşekkür ederiz. (Proje başvuru no: 1919B012330365)
dc.identifier.citationSavcı, S., Kocadağ Kocazorbaz, E., Menfaatli, E., & Gündeğer, E. (2025). Making health out of recycling: The innovative role of hawthorn seed waste in diabetes management. Waste and Biomass Valorization, https://doi.org/10.1007/s12649-025-03266-4
dc.identifier.doi10.1007/s12649-025-03266-4
dc.identifier.issn1877-265X
dc.identifier.issn1877-2641
dc.identifier.issnhttps://doi.org/10.1007/s12649-025-03266-4
dc.identifier.scopus2-s2.0-105013568042
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1090
dc.identifier.wosWOS:001553096300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorGündeğer, Ersin
dc.institutionauthorid0000-0002-4810-6352
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofWaste and Biomass Valorization
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHawthorn Seeds
dc.subjectDiabetes Mellitus
dc.subjectAntidiabetic Potential
dc.subjectIn Silico Studies
dc.subjectWaste Valorization
dc.titleMaking health out of recycling: The innovative role of hawthorn seed waste in diabetes management
dc.typeArticle
dspace.entity.typePublication

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