Nanoemulsions as a promising carrier for topical delivery of etodolac: Formulation development and characterization

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorÜner, Burcu
dc.contributor.authorKaraküçük, Alptuğ
dc.contributor.authorÇelik, Burak
dc.contributor.authorSümer, Engin
dc.contributor.authorTaş, Çetin
dc.date.accessioned2023-11-02T09:06:41Z
dc.date.available2023-11-02T09:06:41Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractThis research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of high shear homogenization and ultrasonication methods. The optimization of the formulation components is systematically conducted using the design of experiments methodology. The droplet size (DS), polydispersity index (PDI), and zeta potential (ZP) of the optimized formulation were assessed using the differential light scattering (DLS) technique. Surface morphology examinations were conducted using electron microscopy, while interactions between excipients and the drug were analyzed through FTIR analysis. Additionally, in vitro release and ex vivo permeability studies were carried out. Furthermore, anti-inflammatory activity was evaluated in the context of a carrageenan-induced paw edema model in rats. The DS, PDI, and ZP of the optimal formulation were 163.5 nm, 0.141, and −33.1 mV, respectively. The in vitro release profile was assessed as a sustained release by following a non-Fickian drug transport. The flux of etodolac nanoemulsions and coarse dispersions were 165.7 ± 11.7 µg/cm2 h and 59.7 ± 15.2 µg/cm2 h, respectively. Enhanced edema inhibition was observed at 13.4%, 36.5%, and 50.65% for the 6th, 8th, and 24th hours, respectively. Taken together, these results confirmed that nanoemulsions are promising carriers for the topical delivery of etodolac.en_US
dc.identifier.citationÖzdemir, S., Üner, B., Karaküçük, A., Çelik, B., Sümer, E., & Taş, Ç. (2023). Nanoemulsions as a promising carrier for topical delivery of etodolac: Formulation development and characterization. Pharmaceutics, 15(10), pp. 1-21. https://doi.org/10.3390/pharmaceutics15102510en_US
dc.identifier.doi10.3390/pharmaceutics15102510en_US
dc.identifier.endpage21en_US
dc.identifier.issn1999-4923
dc.identifier.issue10en_US
dc.identifier.pmidPMID: 37896270en_US
dc.identifier.scopus2-s2.0-85175062015en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics15102510
dc.identifier.urihttps://hdl.handle.net/20.500.13055/574
dc.identifier.volume15en_US
dc.identifier.wosWOS:001093598900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/221S147
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEtodolacen_US
dc.subjectNanoemulsionsen_US
dc.subjectPaw Edemaen_US
dc.subjectPermeationen_US
dc.subjectTopical Drug Deliveryen_US
dc.titleNanoemulsions as a promising carrier for topical delivery of etodolac: Formulation development and characterizationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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