Ovarian stimulation and oocyte cryopreservation in females with cancer

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorOktay, Kutluk H.
dc.contributor.authorTuran, Volkan
dc.date.accessioned2023-07-29T08:55:48Z
dc.date.available2023-07-29T08:55:48Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractPurpose of review: We reviewed the most recent developments including the safety and effectiveness data and success rates in individualized ovarian stimulation protocols for adult and postpubertal females with cancer. Recent findings: In women with breast cancer, aromatase inhibitor- and tamoxifen-supplemented stimulation protocols increase the margin of safety by limiting estrogen exposure. The outcomes of ovarian stimulation appear similar between cancer and noncancer populations, even with the recently developed random-start protocols, which allow initiation of ovarian stimulation anytime during the menstrual cycle. Based on lower anti-Mullerian hormone levels and primordial follicle density, carriers of BRCA pathogenic variants (BRCApv) have decreased ovarian reserve in comparison to women without those variants and may lose larger portion of their ovarian reserve post chemotherapy. Oocyte cryopreservation is also emerging as a suitable fertility preservation approach for selected postpubertal girls as young as 12 years of age. Summary: Individualized ovarian stimulation approaches combined with improvements in cryopreservation techniques increased the success and safety margin to preserve fertility with oocyte freezing. Women with BRCApv, on the other hand, may be at disadvantage as they have lower ovarian reserve and may lose larger portion of their ovarian reserve post chemotherapy compared to women who do not carry these variants.en_US
dc.description.sponsorshipNICHD HD053112 to KO.en_US
dc.identifier.citationOktay, K. H., & Turan, V. (2023). Ovarian stimulation and oocyte cryopreservation in females with cancer. Current Opinion in Oncology, 35(5), pp. 412-419. https://doi.org/10.1097/CCO.0000000000000977en_US
dc.identifier.doi10.1097/CCO.0000000000000977en_US
dc.identifier.endpage419en_US
dc.identifier.issue5en_US
dc.identifier.pmidPMID: 37498110en_US
dc.identifier.scopus2-s2.0-85167476485en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage412en_US
dc.identifier.urihttps://doi.org/10.1097/CCO.0000000000000977
dc.identifier.urihttps://hdl.handle.net/20.500.13055/513
dc.identifier.volume35en_US
dc.identifier.wosWOS:001044463500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCurrent Opinion in Oncologyen_US
dc.relation.publicationcategoryDiÄŸeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBRCA Pathogenic Variantsen_US
dc.subjectCanceren_US
dc.subjectCryopreservationen_US
dc.subjectFertility Preservationen_US
dc.subjectOocyte Freezingen_US
dc.subjectOvarian Stimulationen_US
dc.titleOvarian stimulation and oocyte cryopreservation in females with canceren_US
dc.typeReview Articleen_US
dspace.entity.typePublication

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