A simple UFLC method for the determination of Montelukast in human plasma
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ACG Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma. The method involves pre-column derivatization using 4-bromomethyl-7- methoxycoumarin (BrMmC). The calibration curve linear concentrations from 10 to 1000 ng/mL. The method exhibited an average recovery rate of 95.49%. The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer.
Açıklama
Anahtar Kelimeler
Montelukast, Ultrafast Liquid Chromatography, Fluorescence Detection, 4-Bromomethyl-7-Methoxy Coumarin, Human Plasma
Kaynak
Journal of Chemical Metrology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Önal, C., Kepekçi Tekkeli, Ş. E., & Önal, A. (2024). A simple UFLC method for the determination of Montelukast in human plasma. Journal of Chemical Metrology, pp. 1-5. http://doi.org/10.25135/jcm.114.2407.3262
