A simple UFLC method for the determination of Montelukast in human plasma

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dc.authorid0000-0002-5840-7386
dc.authorid0000-0002-1871-017X
dc.authorid0000-0001-8455-1173
dc.contributor.authorÖnal, Cem
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.contributor.authorÖnal, Armağan
dc.date.accessioned2024-10-16T09:01:07Z
dc.date.available2024-10-16T09:01:07Z
dc.date.issued2024
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractIn this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma. The method involves pre-column derivatization using 4-bromomethyl-7- methoxycoumarin (BrMmC). The calibration curve linear concentrations from 10 to 1000 ng/mL. The method exhibited an average recovery rate of 95.49%. The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer.
dc.identifier.citationÖnal, C., Kepekçi Tekkeli, Ş. E., & Önal, A. (2024). A simple UFLC method for the determination of Montelukast in human plasma. Journal of Chemical Metrology, pp. 1-5. http://doi.org/10.25135/jcm.114.2407.3262
dc.identifier.doi10.25135/jcm.114.2407.3262
dc.identifier.endpage5
dc.identifier.issn1307-6183
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.13055/819
dc.identifier.urihttp://doi.org/10.25135/jcm.114.2407.3262
dc.identifier.wosWOS:001328944200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorÖnal, Cem
dc.institutionauthorKepekçi Tekkeli, Şerife Evrim
dc.institutionauthorid0000-0002-5840-7386
dc.institutionauthorid0000-0002-1871-017X
dc.language.isoen
dc.publisherACG Publications
dc.relation.ispartofJournal of Chemical Metrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMontelukast
dc.subjectUltrafast Liquid Chromatography
dc.subjectFluorescence Detection
dc.subject4-Bromomethyl-7-Methoxy Coumarin
dc.subjectHuman Plasma
dc.titleA simple UFLC method for the determination of Montelukast in human plasma
dc.typeArticle
dspace.entity.typePublication

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