Prospective evaluation of remifentanil-propofol mixture for total intravenous anesthesia: A randomized controlled study

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dc.authorid0000-0002-4305-5226en_US
dc.authorscopusid55587203200en_US
dc.contributor.authorBakan, Mefkur
dc.contributor.authorUmutoğlu, Tarık
dc.contributor.authorTopuz, Ufuk
dc.contributor.authorYılmaz Güler, Emine
dc.contributor.authorUysal, Harun
dc.contributor.authorÖztürk, Erdoğan
dc.date.accessioned2021-12-20T11:57:28Z
dc.date.available2021-12-20T11:57:28Z
dc.date.issued2021en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Anestezi Programıen_US
dc.description.abstractApplication of total intravenous anesthesia (TIVA) may be considered as unpractical when compared with inhalational anesthesia. Although it is mostly not recommended, mixing intravenous agents is popular in clinical practice. The aim of the present study was to investigate the suitability of using remifentanil-propofol mixture (MIXTIVA) for TIVA. Adult patients with an American Society of Anesthesiologists grade of I-II scheduled for elective thyroidectomy were randomly allocated to 3 groups (n=32 for each) to receive TIVA with remifentanil and propofol infusions separately (control group, Group I) or with MIXTIVA infusion that contained remifentanil/propofol at a proportion of 2/1,000 or 3/1,000 (remifentanil concentration, 20 or 30 mu g/ml in 1% propofol in Group II or Group III, respectively). The extubation time (the primary outcome of the study), the orientation time and number of patients in whom intraoperative hypotension, hypertension or bradycardia episodes were encountered during anesthesia were comparable among the groups. The mean remifentanil infusion rate in Group III was significantly higher than that in the other groups. The mean propofol infusion rates and mean bispectral index (BIS) scores during anesthesia were comparable among groups. Hypotension accompanied with a high BIS was encountered in one patient in Group III. In conclusion, compared to the standard TIVA technique using separate drug infusions, MIXTIVA infusion used for thyroidectomies did not result in any statistically significant difference in recovery and clinical outcomes. This technique may be considered as a practical implementation for busy ambulatory centers performing general anesthesia.en_US
dc.identifier.citationBakan, M., Umutoğlu, T., Topuz, U., Güler, E. Y., Uysal, H., & Özturk, E. (2021). Prospective evaluation of remifentanil-propofol mixture for total intravenous anesthesia: A randomized controlled study. Experimental and Therapeutic Medicine, 22(5), pp. 1-7. https://doi.org/10.3892/etm.2021.10632en_US
dc.identifier.doi10.3892/etm.2021.10632en_US
dc.identifier.endpage7en_US
dc.identifier.issue5en_US
dc.identifier.pmidPMID: 34584543en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2021.10632
dc.identifier.urihttps://hdl.handle.net/20.500.13055/97
dc.identifier.volume22en_US
dc.identifier.wosWOS:000693635700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorUmutoğlu, Tarık
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTotal Intravenous Anesthesiaen_US
dc.subjectPropofolen_US
dc.subjectRemifentanilen_US
dc.subjectPropofol-Remifentanil Mixtureen_US
dc.subjectIntravenous Admixtureen_US
dc.subjectBispectral Index Monitoringen_US
dc.titleProspective evaluation of remifentanil-propofol mixture for total intravenous anesthesia: A randomized controlled studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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