Designing a sustainable extraction platform using deep eutectic solvents: Valorization of sidr leaves into bioactive-rich fractions

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dc.authorid0000-0002-9989-9823
dc.authorid0000-0003-2351-172X
dc.authorid0000-0002-2241-2562
dc.authorid0000-0001-9870-8514
dc.contributor.authorŞahin, Selin
dc.contributor.authorBozkurt, Rabia Nur
dc.contributor.authorKurtulbaş, Ebru
dc.contributor.authorToprakçı, İrem
dc.date.accessioned2026-07-13T13:25:36Z
dc.date.available2026-07-13T13:25:36Z
dc.date.issued2026
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractSidr (Ziziphus spina-christi L.) leaves are a potential source of phenolic bioactives exhibiting promising an tioxidant properties. A sustainable extraction system based on deep eutectic solvents (DESs) was developed for the recovery of bioactive-rich extract from Sidr leaves in the present study. Methods: Six DES systems prepared from glycerol with lactic acid or propionic acid were screened. Fourier transform infrared (FTIR) spectroscopy confirmed DES formation through shifts and broadening of characteristic bands associated with hydrogen bonding interactions. Glycerol:propionic acid (1:1) was selected as the most effective solvent by principal component analysis (PCA). Extraction parameters were optimized by Box- Behnken design using immersion time, water addition and sample mass as variables. Results: Total phenolic content (TPC) were between 10.10 mg-GAE/g-DM and 61.23 mg-GAE/g-DM, while rutin content varied from 4.69 mg/g to 32.50 mg/g. Water addition was the most influential factor for phenolic recovery. The optimized conditions were 30 min, 30% water addition and 0.948 g sample mass. Antioxidant activity correlated with TPC and total flavonoid content (TFC). Conclusion: Antioxidant capacity of the Sidr leaf extract is mostly contributed by phenolic matrix rather than an individual compound.
dc.identifier.citationŞahin, S., Bozkurt, R. N., Kurtulbaş, E., & Toprakçı, İ. (2026). Designing a sustainable extraction platform using deep eutectic solvents: Valorization of sidr leaves into bioactive-rich fractions. Natural Product Communications, 21(7), pp. 1-14. https://doi.org/10.1177/1934578X261467196
dc.identifier.doi10.1177/1934578X261467196
dc.identifier.endpage14
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1177/1934578X261467196
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1538
dc.identifier.volume21
dc.identifier.wosWOS:001814281700001
dc.identifier.wos2-s2.0-105044313360
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBozkurt, Rabia Nur
dc.institutionauthorid0000-0003-2351-172X
dc.language.isoen
dc.publisherSAGE Publications
dc.relation.ispartofNatural Product Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectZiziphus Spina-Christi
dc.subjectSustainable Extraction
dc.subjectNatural Deep Eutectic Solvents
dc.subjectAntioxidant Capacity
dc.subjectMultivariate Optimization
dc.titleDesigning a sustainable extraction platform using deep eutectic solvents: Valorization of sidr leaves into bioactive-rich fractions
dc.typeArticle
dspace.entity.typePublication

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