The effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength

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dc.authorid0000-0002-6424-7411en_US
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorSevim, Altuğ Mert
dc.contributor.authorÇınar, Kamil
dc.contributor.authorYaşa Atmaca, Göknur
dc.contributor.authorErdoğmuş, Ali
dc.date.accessioned2021-12-23T13:20:56Z
dc.date.available2021-12-23T13:20:56Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractPhotodynamic therapy (PDT) is an alternative way to treat the cancer non-surgically with minimum harm, in which a specific light and light sensitive photosensitizer (PS) is used. This study deals with the utilization of zinc photosensitizers (λmax ∼700 nm) from the group of phthalocyanines in photodynamic therapy. The photosensitizers differed in bearing either tetra- or octa-mercaptopropionic acid groups. The phthalocyanines (L1ZnPc and DipZnPc) were tested in cancer cell line, HeLa cell (epitheloid cervix carcinoma), by dark and light cytotoxicity. The photophysico-chemical properties of the resulting zinc photosensitizers were analyzed and to investigate the singlet oxygen's efficiency, photochemical properties were determined. For L1ZnPc, the singlet oxygen quantum yield was ΦΔ = 0.41 and for DipZnPc, the value was ΦΔ = 0.27. In addition to the experimental outcomes, this study handles detailed calculations of the absorbed light dose by the photosensitizer at a specific wavelength. In the light of this study, the researchers could get the insight of the precise amount of energy delivered to the cells by a laser beam for critical applications. The absorbed dose of the laser irradiation was calculated within a true wavelength range that is the most detailed explanation in literature.en_US
dc.identifier.citationYurttaş, A. G., Sevim, A. M., Çınar, K., Atmaca, G. Y., Erdoğmuş, A., & Gül, A. (2022). The effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelength. Dyes and Pigments, 198. pp. 1-8. https://doi.org/10.1016/j.dyepig.2021.110012en_US
dc.identifier.doi10.1016/j.dyepig.2021.110012en_US
dc.identifier.endpage8en_US
dc.identifier.scopus2-s2.0-85120781957en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.dyepig.2021.110012
dc.identifier.urihttps://hdl.handle.net/20.500.13055/111
dc.identifier.volume198en_US
dc.identifier.wosWOS:000743584800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofDyes and Pigmentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbsorbed Fluenceen_US
dc.subjectDark Cytotoxicityen_US
dc.subjectLaser Fluenceen_US
dc.subjectLight Cytotoxicityen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectPhthalocyanineen_US
dc.titleThe effects of zinc(II)phthalocyanine photosensitizers on biological activities of epitheloid cervix carcinoma cells and precise determination of absorbed fluence at a specific wavelengthen_US
dc.typeArticleen_US
dspace.entity.typePublication

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