Considering its mechanism of action it may be logical to choose letrozole as an initial option for endometrium preparation before vitrified-warmed embryo transfer

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dc.authorid0000-0002-5638-3675
dc.authorid0000-0002-9277-7735
dc.authorid0000-0001-8892-3974
dc.authorid0000-0002-1953-2475
dc.authorid0000-0001-7660-8344
dc.contributor.authorAydın, Gerçek
dc.contributor.authorAslan, Kiper
dc.contributor.authorAraç, Merve
dc.contributor.authorErgin, Elif
dc.contributor.authorKasapoğlu, Işıl
dc.contributor.authorUncu, Gürkan
dc.date.accessioned2025-08-26T13:21:47Z
dc.date.available2025-08-26T13:21:47Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractAim: To assess the efficacy of letrozole and programmed hormone replacement therapy (HRT) cycles in terms of obstetric outcomes for women undergoing a single vitrified-warmed blastocyst embryo transfer (SVBT). Methods: This study is a retrospective study conducted in a private IVF (in vitro fertilization) clinic. A total of 324 FET cycles (letrozole group = 183, HRT = 141), consisting of primary infertile patients aged <40 years, were enrolled. The cycle characteristics, pregnancy results, and perinatal parameters were recorded. The primary outcomes of this study are pregnancy and miscarriage rates, live birth rates, whereas hypertensive disease of pregnancy (HDP), intrauterine growth restriction (IUGR) and preterm birth are the secondary outcomes. Results: Positive β-HCG rates were 53% (97/183) versus 61% (86/141), whereas clinical pregnancy rates were 47% (86/183) versus 51.1% (72/141) for the letrozole and HRT groups, respectively. For clinical miscarriage, the results were 6.5% (12/183) for letrozole versus 15.6% (22/141) for HRT groups, which were statistically significant. For live birth rate (LBR), letrozole was found to be slightly better compared to HRT 40.4% (74/183) versus 35.5% (50/141). Considering the perinatal outcomes, the parameters were comparable between the groups. Conclusions: In terms of perinatal outcomes and IVF success, letrozole was not found to be inferior to HRT. Letrozole can be utilized as a safe and effective agent, even as a first-line treatment, given the potential benefits offered by its mechanism of action and being a reasonable option for both ovulatory and unovulatory patients.
dc.identifier.citationAydın, G., Aslan, K., Araç, M., Ergin, E., Kasapoğlu, I., & Uncu, G. (2025). Considering its mechanism of action it may be logical to choose letrozole as an initial option for endometrium preparation before vitrified-warmed embryo transfer. Journal of Obstetrics and Gynaecology Research, 51(8), pp. 1-9. https://doi.org/10.1111/jog.70048
dc.identifier.doi10.1111/jog.70048
dc.identifier.endpage9
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue8
dc.identifier.pmidPMID: 40847668
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1111/jog.70048
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1086
dc.identifier.volume51
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAydın, Gerçek
dc.institutionauthorid0000-0002-5638-3675
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHRT
dc.subjectEndometrial Preparation
dc.subjectFrozen Embryo Transfer
dc.subjectLetrozole
dc.titleConsidering its mechanism of action it may be logical to choose letrozole as an initial option for endometrium preparation before vitrified-warmed embryo transfer
dc.typeArticle
dspace.entity.typePublication

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