Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: A meta-analysis

dc.authorid0000-0003-2287-799X
dc.authorid0000-0003-1966-3886
dc.authorid0000-0002-5755-9951
dc.authorid0000-0003-0914-7757
dc.contributor.authorTuran, Volkan
dc.contributor.authorÖktem, Özgür
dc.contributor.authorBang, Heejung
dc.contributor.authorOktay, Kutluk Han
dc.date.accessioned2025-07-26T14:35:37Z
dc.date.available2025-07-26T14:35:37Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractOur aim was to assess fertility preservation (the proportion of women who had at least 1 live birth) and utilization rates (the proportion of women who utilized their cryopreserved embryos) rates among women who cryopreserved their embryos before breast cancer treatments. PubMed and Cochrane library database were searched until December 2024. We included all studies that reported pregnancy outcomes, the number of women who returned for frozen embryo transfer, and the number of women who preserved their fertility. The primary outcome measures were the utilization and fertility preservation rates. Secondary outcome measures were implantation, clinical pregnancy, and live birth rates. Of the 12 studies, 9 met the criteria, encompassing >2126 women with breast cancer who cryopreserved their embryos for fertility preservation. In 9 studies that reported the total number of attempts, 424 women underwent 863 embryo transfers. Based on those studies, the clinical pregnancy and live birth rates were 50% (95% CI: 35-65, I 2: 80%) and 33% (95% CI: 22-46, I 2: 76%), respectively. The utilization and fertility preservation rates were 18% (95% CI: 9-32, I 2: 95%) and 39% (95% CI: 29-51, I 2: 48%), respectively, all from random-effects models. Fertility preservation success with embryos cryopreserved before breast cancer treatments seems to be promising. However, the utilization rate of cryopreserved embryos is low. Additional studies with larger sample size and longer follow up are required to evaluate the long-term utility rates.
dc.identifier.citationTuran, V., Öktem, Ö., Bang, H., & Oktay, K. H. (2025). Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: A meta-analysis. Clinical Breast Cancer, pp. 1-8. https://doi.org/10.1016/j.clbc.2025.06.003
dc.identifier.doi10.1016/j.clbc.2025.06.003
dc.identifier.endpage8
dc.identifier.issn1938-0666
dc.identifier.issn1526-8209
dc.identifier.pmidPMID: 40603132
dc.identifier.scopus2-s2.0-105009594956
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.clbc.2025.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1041
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTuran, Volkan
dc.institutionauthorid0000-0003-2287-799X
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical Breast Cancer
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFrozen Embryo Transfer
dc.subjectLive Birth
dc.subjectPregnancy Outcome
dc.subjectBreast Cancer
dc.subjectFertility Preservation
dc.titleUtilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: A meta-analysis
dc.typeReview Article
dspace.entity.typePublication

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