Characterizing the amniotic fluid-derived stem cells and optimizing the passage number for targeted applications

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dc.authorid0000-0003-4470-7465
dc.authorid0000-0003-0975-1989
dc.authorid0000-0001-7580-3412
dc.contributor.authorDikmen, Tayfun
dc.contributor.authorErdoǧan, Metin
dc.contributor.authorAltunbaş, Korhan
dc.date.accessioned2024-11-05T07:36:01Z
dc.date.available2024-11-05T07:36:01Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractMesenchymal stem cells are considered potent sources that can be used for tissue regeneration and treatment of various diseases and syndromes. Among the mesenchymal stem cells, amniotic fluid-derived stem cells come forward as they possess some pluripotent properties and there are no serious ethical concerns upon their derivation. Therefore, gaining a better understanding of the nature of amniotic fluid stem cells is important. Although it is known that stem cells show slightly different characteristics between passages, scientists often consider only cell numbers and the proliferation pattern of the cells when deciding the passage to use in their studies. In this study, it was aimed to characterize rat amniotic fluid-derived stem cells for their mesenchymal and pluripotent features and make inter-passage comparisons by real-time qPCR to reveal their distinctions between different passages, and eventually help decide the appropriate passage numbers to be used in future research. The outcomes of the study showed that using rat amniotic fluid-derived stem cells at P5 could be beneficial for mesodermal differentiation studies and using them in earlier passages may be more favorable for the studies requiring better ectodermal differentiation properties.
dc.identifier.citationDikmen, T., Erdoğan, M., & Altunbaş, K. (2024). Characterizing the amniotic fluid-derived stem cells and optimizing the passage number for targeted applications. Pakistan Veterinary Journal, 44(3), pp. 854-860. http://dx.doi.org/10.29261/pakvetj/2024.226
dc.identifier.doi10.29261/pakvetj/2024.226
dc.identifier.endpage860
dc.identifier.issn0253-8318
dc.identifier.issn2074-7764
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85207266465
dc.identifier.scopusqualityQ1
dc.identifier.startpage854
dc.identifier.urihttp://dx.doi.org/10.29261/pakvetj/2024.226
dc.identifier.urihttps://hdl.handle.net/20.500.13055/845
dc.identifier.volume44
dc.identifier.wosWOS:001338554500022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDikmen, Tayfun
dc.institutionauthorid0000-0003-4470-7465
dc.language.isoen
dc.publisherFaculty Of Veterinary Science, University Of Agriculture
dc.relation.ispartofPakistan Veterinary Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmniotic Fluid
dc.subjectAmniotic Fluid-Derived Stem Cells
dc.subjectDifferentiation
dc.subjectInter-Passage Difference
dc.subjectMesenchymal
dc.subjectPluripotent
dc.titleCharacterizing the amniotic fluid-derived stem cells and optimizing the passage number for targeted applications
dc.typeArticle
dspace.entity.typePublication

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