A dual-drug nanocarrier strategy for ocular fungal infections: Micelles embedded in electrospun nanofibers

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dc.authorid0000-0002-8658-3723
dc.authorid0000-0001-5724-9809
dc.authorid0000-0002-8449-548X
dc.authorid0000-0003-0823-631X
dc.authorid0000-0002-9110-3704
dc.contributor.authorUzel, Egemen
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorAydilek, Neriman
dc.contributor.authorHacıoğlu, Mayram
dc.contributor.authorGüngör, Sevgi
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2026-04-19T14:15:12Z
dc.date.available2026-04-19T14:15:12Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractOcular fungal diseases are associated with severe infection and pain and, in advanced stages, can lead to vision loss. Current treatment options are limited to the topical ap plication of conventional drugs, and the bioavailability of these drugs is quite limited due to ocular barriers. In this study, a dual-drug nanodelivery system was developed to improve intraocular drug delivery by combining antifungal and anti-inflammatory therapies. Posaconazole (PSC), a broad-spectrum triazole antifungal agent, and dexke toprofen trometamol (DKP), a rapidly acting nonsteroidal anti-inflammatory drug, were co-loaded onto polymeric micelles and then incorporated into electrospun poly(vinyl alco hol)/poly(vinylpyrrolidone) (PVA/PVP) nanofiber intraocular implants. DSC, XRD, FTIR, and FESEM analyses showed that both APIs were successfully converted into nanofiber form without disrupting the micelle structure. Comparative studies with DKP solution and PSC commercial oral suspension (Noxafil® 40 mg/mL) showed that the produced micelle loaded nanofibers provided sustained release and significantly increased ex vivo ocular permeation and penetration. In vitro antifungal activity tests demonstrated efficacy against Candida albicans, and HET-CAM toxicity tests showed that the micelle-loaded nanofibers were non-irritating and suitable for ocular application. Overall, the micelle-loaded electro spun nanofiber ocular inserts developed in this study represent a promising platform for combined antifungal and anti-inflammatory ocular therapy.
dc.description.sponsorshipThis research was funded by the Research Fund of Istanbul University (project no: 38014). Bu araştırma, İstanbul Üniversitesi Araştırma Fonu tarafından finanse edilmiştir (proje no: 38014).
dc.identifier.citationUzel, E., Durgun, M. E., Aydilek, N., Hacıoğlu, M., Güngör, S., & Özsoy, Y. (2026). A dual-drug nanocarrier strategy for ocular fungal infections: Micelles embedded in electrospun nanofibers. Molecules, 31(8), pp. 1-32. https://doi.org/10.3390/molecules31081235
dc.identifier.doi10.3390/molecules31081235
dc.identifier.endpage32
dc.identifier.issn1420-3049
dc.identifier.issue8
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/molecules31081235
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1432
dc.identifier.volume31
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorDurgun, Meltem Ezgi
dc.institutionauthorid0000-0001-5724-9809
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofMolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOcular Drug Delivery
dc.subjectElectrospinning
dc.subjectNanofiber Inserts
dc.subjectPolymeric Micelles
dc.subjectPosaconazole
dc.subjectDexketoprofen Trometamol
dc.titleA dual-drug nanocarrier strategy for ocular fungal infections: Micelles embedded in electrospun nanofibers
dc.typeArticle
dspace.entity.typePublication

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