Regenerative strategies in pediatric dentistry: A comprehensive overview of tissue engineering from past to future

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dc.authorid0000-0003-1829-0379
dc.authorid0000-0002-3990-7270
dc.authorid0000-0002-7538-1763
dc.authorid0000-0002-0763-3930
dc.authorid0000-0002-1272-5581
dc.contributor.authorŞirinoğlu Çapan, Belen
dc.contributor.authorBirant, Sinem
dc.contributor.authorGümüştaş, Burak
dc.contributor.authorErçal, Pınar
dc.contributor.authorŞişmanoğlu, Soner
dc.date.accessioned2025-08-17T15:54:37Z
dc.date.available2025-08-17T15:54:37Z
dc.date.issued2025
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.description.abstractTissue engineering in pediatric dentistry focuses on regenerating damaged dental tissues in children, aiming to restore their natural functions and address challenges associated with immature teeth. This field applies interdisciplinary biological principles to repair and regenerate tissues, using biomaterials, stem cells, and growth factors. Current advancements emphasize the regeneration of the dentin-pulp complex and tooth development through the use of biomaterials such as collagen, which offers structural support for cell growth and favorable interactions in tissue engineering. Additionally, various growth factors like FGF, TGF-β, BMP, and VEGF play vital roles in tissue regeneration by regulating signaling mechanisms in the dentin-pulp complex. Stem cells, particularly dental-derived ones such as DPSCs, SHEDs, and PDLSCs, have shown great potential in regenerating dental tissues in pediatric patients. These multipotent cells are capable of differentiating into various lineages, including odontoblasts, and are essential for the regeneration of both soft and hard dental tissues. While gene therapy, scaffolding techniques, and advanced technologies like three-dimensional (3D) bioprinting hold promise for tissue engineering, challenges remain in clinical implementation due to high costs and the need for further research. However, tissue engineering has already begun revolutionizing pediatric dental treatments, particularly in regenerative endodontics, and offers a minimally invasive alternative to traditional procedures like root canal treatments for young immature teeth. The future of regenerative dentistry in pediatric care lies in improving the application of stem cell–based therapies and bioactive materials to achieve complete tissue regeneration and provide more effective, personalized care for young patients.
dc.identifier.citationŞirinoğlu Çapan, B., Birant, S., Gümüştaş, B., Erçal, P., & Şişmanoğlu, S. (2025). Regenerative strategies in pediatric dentistry: A comprehensive overview of tissue engineering from past to future. Advances in Experimental Medicine and Biology, pp. 1-29. https://doi.org/10.1007/5584_2025_877
dc.identifier.doi10.1007/5584_2025_877
dc.identifier.endpage29
dc.identifier.issn2214-8019
dc.identifier.issn0065-2598
dc.identifier.pmidPMID: 40778978
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/5584_2025_877
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1077
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorErçal, Pınar
dc.institutionauthorid0000-0002-0763-3930
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofAdvances in Experimental Medicine and Biology
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDental Pulp
dc.subjectDentin
dc.subjectMesenchymal Stem Cells
dc.subjectPediatric Dentistry
dc.subjectRegeneration
dc.subjectTissue Engineering
dc.titleRegenerative strategies in pediatric dentistry: A comprehensive overview of tissue engineering from past to future
dc.typeBook Chapter
dspace.entity.typePublication

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