Loteprednol loaded nanoformulations for corneal delivery by quality by design concepts: Optimization, characterization, and anti infammatory activity

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÜner, Burcu
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorTaş, Çetin
dc.contributor.authorÜner, Melike
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2023-04-03T08:28:57Z
dc.date.available2023-04-03T08:28:57Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractLoteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye discharge, and ocular discomfort. Therefore, it was decided to select the delivery systems, which are solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsion (NE). Design of experiments (DoE) of SLN, NLC, and NE formulations were formulated by using the quality by design (QbD) approach. Precirol® ATO 5 and oleic acid were used as solid and liquid lipids, respectively, in SLN, NLC, and NE formulations. Physiochemical characterization was performed on the formulations. The optimized formulations' inflammatory effects have been appraised on human corneal epithelial cells employing the ELISA test. Physicochemical characterization studies and inflammatory effects were appraised. The sizes of optimized formulations of SLN, NLC, and NE were 86.19 nm, 82.38 nm, and 126.35 nm, respectively, with minimum polydispersity. The release behavior of the formulations is composed of both diffusion and erosion. ELISA test results proved that the formulations significantly reduced IL-1 and IL-6 levels (p < 0.05). D-optimal mixture experimental design allowed us to develop the most precise formulations of SLN, NLC, and NE. Furthermore, the optimized formulations could be promising candidates for treating an inflammation-based corneal disease of the eye.en_US
dc.identifier.citationÜner, B., Özdemir, S., Taş, Ç., Üner, M., & Özsoy, Y. (2023). Loteprednol loaded nanoformulations for corneal delivery by quality by design concepts: Optimization, characterization, and anti infammatory activity. AAPS PharmSciTech, 24(4), pp. 1-15. https://doi.org/10.1208/s12249-023-02551-6en_US
dc.identifier.doi10.1208/s12249-023-02551-6en_US
dc.identifier.endpage15en_US
dc.identifier.issn1530-9932
dc.identifier.issue4en_US
dc.identifier.pmidPMID: 36977841en_US
dc.identifier.scopus2-s2.0-85151113476en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-023-02551-6
dc.identifier.urihttps://hdl.handle.net/20.500.13055/435
dc.identifier.volume24en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAAPS PharmSciTechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesign of Experimentsen_US
dc.subjectLoteprednol Etabonateen_US
dc.subjectNanoemulsionen_US
dc.subjectNanostructured Lipid Carriersen_US
dc.subjectOphthalmic Deliveryen_US
dc.subjectQuality By Designen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectTopical Corticosteroidsen_US
dc.titleLoteprednol loaded nanoformulations for corneal delivery by quality by design concepts: Optimization, characterization, and anti infammatory activityen_US
dc.typeArticleen_US
dspace.entity.typePublication

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