Timolol-loaded ethosomes for ophthalmic delivery: Reduction of high intraocular pressure in vivo

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÜner, Burcu
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorPilevne, Şeniz Nur
dc.contributor.authorÇelebi, Ali Rıza Cenk
dc.date.accessioned2023-05-08T07:25:33Z
dc.date.available2023-05-08T07:25:33Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractThe beta-adrenoceptor blocker timolol maleate (TML) is a commonly used pharmaceutical agent for the management of glaucoma. Conventional eye drops have limitations due to biological or pharmaceutical factors. Therefore, TML-loaded ethosomes have been designed to mitigate these restrictions and give a viable solution for reducing elevated intraocular pressure (IOP). The ethosomes were prepared using the thin film hydration method. Integrating the Box-Behnken experimental strategy, the optimal formulation was identified. The physicochemical characterization studies were performed on the optimal formulation. Then, in vitro release and ex vivo permeation studies were conducted. The irritation assessment was also carried out with Hen's Egg Test–Chorioallantoic Membrane model (HET-CAM), and in vivo evaluation of the IOP lowering effect was also performed on rats. The physicochemical characterization studies demonstrated that the components of the formulation were compatible with each other. The particle size, zeta potential, and encapsulation efficiency (EE%) were found as 88.23 ± 1.25 nm, -28.7 ± 2.03 mV, and 89.73 ± 0.42 %, respectively. The in vitro drug release mechanism was found as Korsmeyer-Peppas kinetics (R2=0.9923). The HET-CAM findings verified the formulation's eligibility for biological applications. The IOP measurements revealed no statistical difference (p>0.05) between the once-a-day application of the optimal formulation and the three-times-a-day application of the conventional eye drop. A similar pharmacological response was observed at lowered application frequencies. Therefore, it was concluded that the novel TML-loaded ethosomes could be a safe and efficient alternative for glaucoma treatment.en_US
dc.description.sponsorshipAcıbadem University Scientific Research Projects Coordination Unit -- ABAPKO: 2022/01-32en_US
dc.identifier.citationÜner, B., Özdemir, S., Pilevne, Ş. N., & Çelebi, A. R. C. (2023). Timolol-loaded ethosomes for ophthalmic delivery: Reduction of high intraocular pressure in vivo. International Journal of Pharmaceutics, 640, pp. 1-14. https://doi.org/10.1016/j.ijpharm.2023.123021en_US
dc.identifier.doi10.1016/j.ijpharm.2023.123021en_US
dc.identifier.endpage14en_US
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.pmidPMID: 37149109en_US
dc.identifier.scopus2-s2.0-85158875218en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2023.123021
dc.identifier.urihttps://hdl.handle.net/20.500.13055/456
dc.identifier.volume640en_US
dc.identifier.wosWOS:001005099400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Pharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBox-Behnken Designen_US
dc.subjectTimolol Maleateen_US
dc.subjectEthosomeen_US
dc.subjectHET-CAMen_US
dc.subjectOphthalmic Drug Deliveryen_US
dc.titleTimolol-loaded ethosomes for ophthalmic delivery: Reduction of high intraocular pressure in vivoen_US
dc.typeArticleen_US
dspace.entity.typePublication

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