Elucidating deep eutectic solvent-mediated recovery of phenolic compounds from cubeb pepper (piper cubeba l.f.) and their antioxidant potential

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dc.authorid0000-0003-2351-172X
dc.authorid0000-0002-2241-2562
dc.authorid0000-0001-9870-8514
dc.authorid0000-0001-8982-2219
dc.contributor.authorBozkurt, Rabia Nur
dc.contributor.authorKurtulbaş, Ebru
dc.contributor.authorToprakçı, İrem
dc.contributor.authorTopraksever, Nükte
dc.date.accessioned2026-07-13T14:00:41Z
dc.date.available2026-07-13T14:00:41Z
dc.date.issued2026
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractObjective: Conventional extraction methods for phenolic recovery often rely on large amounts of organic solvents and may exhibit limited efficiency. This study aimed to develop and optimize a sustainable deep eutectic solvent (DES)-assisted automatic solvent extraction (ASE) process for the recovery of phenolic compounds from Piper cubeba L.f. fruits. Methods: Prepared DES systems were characterized by Fourier-transform infrared (FTIR) spectroscopy to confirm DES formation and investigate intermolecular hydrogen-bond interactions between their constituent components. Different DES systems were screened and compared using principal component analysis (PCA) to identify the most effective extraction medium. The selected DES system, lactic acid:ethylene glycol (2:1), was subsequently optimized using response surface methodology (RSM) based on a Box–Behnken design. Immersion time, water addition, and sample mass were evaluated as the main extraction variables. Results: The extraction parameters significantly influenced total phenolic content (TPC), antioxidant activity, and 2-hydroxycinnamic acid recovery. TPC values ranged from 25.55 to 71.54 mg-GAE/g-DM. Antioxidant activity varied between 17.41 and 32.90 mg-TEAC/g-DM for the DPPH assay and between 8.93 and 32.51 mg-TEAC/g-DM for the ABTS assay. The content of 2-hydroxycinnamic acid ranged from 5.95 to 26.12 mg/g-DM. Optimum extraction conditions were determined as 24.95 min immersion time, 52.55% water addition, and 0.70 g sample mass, with prediction errors below 2%. Conclusion: DES-assisted ASE enabled efficient phenolic recovery and accurate process optimization, demonstrating its potential as a sustainable alternative to conventional solvent-based extraction methods. The findings highlight the suitability of the lactic acid:ethylene glycol (2:1) DES system for enhancing the extraction of bioactive compounds from P. cubeba fruits and support its potential application in food, nutraceutical, pharmaceutical, and cosmetic formulations.
dc.identifier.citationBozkurt, R. N., Kurtulbaş, E., Toprakçı, İ., & Topraksever, N. (2026). Elucidating deep eutectic solvent-mediated recovery of phenolic compounds from cubeb pepper (piper cubeba l.f.) and their antioxidant potential. Natural Product Communications, 21(7), pp. 1-16. https://doi.org/10.1177/1934578X261468522
dc.identifier.doi10.1177/1934578X261468522
dc.identifier.endpage16
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.issue7
dc.identifier.scopus2-s2.0-105044343228
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1177/1934578X261468522
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1539
dc.identifier.volume21
dc.identifier.wosWOS:001816619600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorBozkurt, Rabia Nur
dc.institutionauthorTopraksever, Nükte
dc.institutionauthorid0000-0003-2351-172X
dc.institutionauthorid0000-0001-8982-2219
dc.language.isoen
dc.publisherSAGE Publications
dc.relation.ispartofNatural Product Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutomatic Solvent Extraction
dc.subjectGreen Solvents
dc.subjectResponse Surface Methodology
dc.subjectPhenolic Compounds
dc.subjectPrincipal Component Analysis
dc.titleElucidating deep eutectic solvent-mediated recovery of phenolic compounds from cubeb pepper (piper cubeba l.f.) and their antioxidant potential
dc.typeArticle
dspace.entity.typePublication

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