The historical relationship between meis1 and leukemia

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dc.contributor.authorMeriç, Neslihan
dc.contributor.authorKocabaş, Fatih
dc.date.accessioned2022-03-21T10:40:50Z
dc.date.available2022-03-21T10:40:50Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıp Tarihi ve Etik Ana Bilim Dalıen_US
dc.description.abstractAcute leukemia (AL) is a poor progressive resistant hematological disease, which has different subtypes and immunophenotypic properties according to leukemic blasts. AL is caused by genetic changes and associated with leukemia stem cells (LSCs), which determine its prognosis and endurance. LSCs are thought to be hematopoietic progenitor and stem cell (HPSCs)-like cells that underwent a malignant transformation. In addition to their low number, LSCs have the characteristics of self-renewal, resistance to chemotherapy, and relapse of leukemia. The myeloid ecotropic integration site-1 (MEIS1) protein is a member of the three-amino acid loop extension (TALE) family of homeodomain (HD) proteins that can bind to DNA sequence-specific manner. Studies have shown that overexpression of MEIS1 and associated cofactors involves tumorigenesis of numerous cancers. Historically, increased expression of Meis1 transcript as well as protein has been determined in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients. Moreover, resistance to conventional chemotherapy was observed in leukemic blast samples with high Meis1 content. In this review article, the molecular mechanism of the oncological role of the MEIS1 protein in leukemia and LSC is discussed. In addition, it was suggested that MEIS1 protein could be utilized as a possible treatment target in leukemia with an emphasis on the inhibition of MEIS1, which is overexpressed in LSC.en_US
dc.identifier.citationMeriç, N. & Kocabaş, F. (2022). The Historical Relationship Between Meis1 and Leukemia. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 16. Advances in Experimental Medicine and Biology, 1387, 127-144. Springer, Cham. https://doi.org/10.1007/5584_2021_705en_US
dc.identifier.doi10.1007/5584_2021_705en_US
dc.identifier.endpage144en_US
dc.identifier.isbn9783031106378
dc.identifier.isbn9783031106385
dc.identifier.pmidPMID: 35304708en_US
dc.identifier.scopus2-s2.0-85135382773en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1007/5584_2021_705
dc.identifier.urihttps://hdl.handle.net/20.500.13055/205
dc.identifier.volume1387en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMeriç, Neslihan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Experimental Medicine and Biologyen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeukemiaen_US
dc.subjectMEIS1en_US
dc.subjectLeukemia Stem Cellsen_US
dc.titleThe historical relationship between meis1 and leukemiaen_US
dc.typeBook Chapteren_US
dspace.entity.typePublication

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