Whole genome expression analysis identifies multiple targeted ıntegrative effects of polyphenol-rich propolis on HER-2-Positive breast cancer cell line

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dc.authorid0000-0002-3635-8421en_US
dc.authorscopusid57194783843en_US
dc.authorwosidDVP-7029-2022en_US
dc.contributor.authorSeyhan, Mehmet Fatih
dc.contributor.authorTimirci Kahraman, Özlem
dc.contributor.authorEronat, Allison Pınar
dc.contributor.authorYılmaz, Eren
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorKısakesen, Halil İbrahim
dc.contributor.authorÖztürk, Tülin
dc.contributor.authorYılmaz-Aydoğan, Hülya
dc.contributor.authorÖztürk, Oğuz
dc.date.accessioned2024-03-01T08:06:35Z
dc.date.available2024-03-01T08:06:35Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalıen_US
dc.description.abstractNatural products have been focused by researchers due to their important anticarcinogenic characteristics in the treatment of cancer with the slightest side effects possible. Propolis is one of the most prominent candidates among these natural products in terms of its anticancer features. In this study we aim to research the effects of Anatolian propolis on ER/PR-, HER-2/neu+ human breast cancer cell line SK-BR-3 with intent to clarify the molecular mechanism propolis in HER+ breast cancers in overview of whole genomic expression for the first time via a microarray experiment. Afterwards, microarray data was validated via real time PCR with the selected genes. After performing bioinformatic analysis via GeneSpring Software and String analysis, a 50 µg/mL dose of propolis affected several pathways of HER-2 positive breast cancer cells including cell cycle, DNA repair and apoptosis especially at 48th hour exposure. In contrast, after exposure to 50 µg/mL dose of propolis, up-regulated genes were detected at diverse pathways such as immune response, cell migration regulation, organization of cell-cell adhesion, etc. For this reason, we proposed that polyphenol-rich propolis can be used in the treatment of HER-2 positive breast cancer with characteristics of less toxic than the current treatment methods.en_US
dc.description.sponsorshipIstanbul Development Agency -- ISTKA/2010/KBO-62en_US
dc.identifier.citationSeyhan, M. F., Timirci Kahraman, Ö., Eronat, A. P., Yılmaz, E., Ceviz, A. B., Kısakesen, H. İ., Öztürk, T., Yılmaz-Aydoğan, H., & Öztürk, O. (2024). Whole genome expression analysis identifies multiple targeted ıntegrative effects of polyphenol-rich propolis on HER-2-Positive breast cancer cell line. Disaster Medicine and Public Health Preparedness, 18(2), pp. 201-211. http://doi.org/10.25135/rnp.437.23.10.2947en_US
dc.identifier.doi10.25135/rnp.437.23.10.2947en_US
dc.identifier.endpage211en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85188952407en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage201en_US
dc.identifier.urihttp://doi.org/10.25135/rnp.437.23.10.2947
dc.identifier.urihttps://hdl.handle.net/20.500.13055/659
dc.identifier.volume18en_US
dc.identifier.wosWOS:001161925600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorCeviz, Ayşe Begüm
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords Of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectHER-2en_US
dc.subjectMicroarrayen_US
dc.subjectFlavonoidsen_US
dc.subjectBioinformaticsen_US
dc.titleWhole genome expression analysis identifies multiple targeted ıntegrative effects of polyphenol-rich propolis on HER-2-Positive breast cancer cell lineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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