Comparison of the effects of four laser wavelengths on Medication-Related Osteonecrosis of the Jaw (MRONJ) in a murine model: An in vivo photobiomodulation study

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dc.authorid0000-0001-5532-9514
dc.authorid0000-0002-1797-5889
dc.authorid0000-0002-2152-8598
dc.authorid0000-0002-5435-706X
dc.authorid0000-0003-2933-3119
dc.authorid0000-0002-4044-3573
dc.contributor.authorAyhan, Mustafa
dc.contributor.authorGedik, Betül
dc.contributor.authorKalelioğlu, Ekrem Emir
dc.contributor.authorKundakçıoğlu, Abdulsamet
dc.contributor.authorKüçükgergin, Canan
dc.contributor.authorTurgut, Cevat Tuğrul
dc.contributor.authorKocaelli, Hümeyra
dc.contributor.authorAlatlı, Fatma Canan
dc.contributor.authorİşsever, Halim
dc.contributor.authorAdemoğlu, Evin
dc.contributor.authorYaltırık, Mehmet
dc.date.accessioned2024-11-15T07:10:02Z
dc.date.available2024-11-15T07:10:02Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractBackground: This study aims to investigate the effectiveness of lasers at various wavelengths in treating medication-related osteonecrosis of the jaw (MRONJ) using biochemical, clinical scoring, micro CT analysis, and histopathological methods. The study follows the ARRIVE guidelines to ensure robust and transparent research. Methods: In our study, there were 6 groups, including one SHAM group, one CONTROL group, and four experimental groups, with 8 rats in each individual group. Each rat received antiresorptive drug intraperitoneally for 4 weeks and then had the left second molar in the mandible extracted. All animals were sacrificed at the end of the 12th week. In the experimental groups, lasers at wavelengths of 405nm, 445nm, 660nm, and 808nm were applied to the animals. Parameters such as serum vitamin D levels, bone density and bone volume at the extraction site, new bone formation, dead bone count, inflammatory cell count, and epithelial regeneration were examined. Additionally, clinical scoring was conducted after sacrifice. The laser parameters included power density, area, time, fluence, and mode (continuous wave), and the light was administered using a fiber with a Gaussian profile. Statistical analyses were performed with the NCSS (Number Cruncher Statistical System) 2007 Statistical Software (Utah, USA) package program. The results were evaluated at the p<0.05 significance level. Results: According to the results obtained from our study, new bone formation in all experimental groups was significantly higher than in the SHAM and CONTROL groups. Furthermore, the 660nm and 808nm wavelengths increased serum vitamin D levels significantly. The most successful outcomes were observed in clinical scoring, dead bone count, epithelial cell regeneration, and bone density in the 660nm and 808nm wavelength groups. Conclusions: The combined use of lasers at 660nm and 808nm wavelengths may yield successful results in treating MRONJ.
dc.identifier.citationAyhan, M., Gedik, B., Kalelioğlu, E. E., Kundakçıoğlu, A., Küçükgergin, C., Turgut, C. T., Kocaelli, H., Alatlı, F. C., İşsever, H., Ademoğlu, E. & Yaltırık, M. (2024). Comparison of the effects of four laser wavelengths on Medication-Related Osteonecrosis of the Jaw (MRONJ) in a murine model: An in vivo photobiomodulation study. International Journal of Medical Sciences, 21(15), 2959-2973. https://doi.org/10.7150/ijms.93224
dc.identifier.doi10.7150/ijms.93224
dc.identifier.endpage2973
dc.identifier.issn1449-1907
dc.identifier.issue15
dc.identifier.pmidPMID: 39628679
dc.identifier.scopus2-s2.0-85209942442
dc.identifier.scopusqualityQ1
dc.identifier.startpage2959
dc.identifier.urihttps://doi.org/10.7150/ijms.93224
dc.identifier.urihttps://hdl.handle.net/20.500.13055/854
dc.identifier.volume21
dc.identifier.wosWOS: 001363267400008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAlatlı, Fatma Canan
dc.institutionauthorid0000-0002-2152-8598
dc.language.isoen
dc.publisherIvyspring International Publisher
dc.relation.ispartofInternational Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak217S985
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPhotobiomodulation Therapy
dc.subjectLaser Therapy
dc.subjectMedication-Related Osteonecrosis of The Jaw
dc.subjectZoledronate
dc.subjectVitamin D
dc.subjectDentistry
dc.subjectOral Surgery
dc.titleComparison of the effects of four laser wavelengths on Medication-Related Osteonecrosis of the Jaw (MRONJ) in a murine model: An in vivo photobiomodulation study
dc.typeArticle
dspace.entity.typePublication

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