Effect of a decellularized omentum scaffold with combination of mesenchymal stem cells and platelet-rich plasma on healing of critical-sized bone defect: A rat model

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dc.authorid0000-0003-3055-8518en_US
dc.authorscopusid57219307968en_US
dc.authorwosidAAD-9922-2021en_US
dc.contributor.authorEmet, Abdulsamet
dc.contributor.authorÖzdemir, Erdi
dc.contributor.authorUçkan Çetinkaya, Duygu
dc.contributor.authorKılıç, Emine
dc.contributor.authorHashemihesar, Ramin
dc.contributor.authorYürüker, Ali Celalettin Sinan
dc.contributor.authorTurhan, Egemen
dc.date.accessioned2021-12-07T06:18:57Z
dc.date.available2021-12-07T06:18:57Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe high costs and extensive time needed for the treatment of critical-sized bone defects are still major clinical concerns in orthopedic surgery; therefore, researchers continue to look for more cost and time-effective methods. This study aims to investigate the effects of a decellularized omentum scaffold with a combination of platelet-rich plasma (PRP) and mesenchymal stem cells on the healing of critical-sized bone defects. Wistar albino rats (n = 30) were investigated in five groups. Critical-sized bone defects were formed on bilateral radius shafts. No scaffold, decellularized omentum, omentum with PRP and omentum + mesenchymal stem cells was used in group 1 (control group), 2, 3 and 4, respectively. In addition, omentum with a combination of mesenchymal stem cells +PRP was used in group 5. After 6 weeks, both radiological and histological healing were evaluated comparatively among the groups. After the use of a decellularized omentum scaffold, vitality of new cells was maintained, and new bone formation occurred. When compared to the control group, radiological healing was significantly better (p = 0.047) in the omentum and omentum + PRP-treated groups. Furthermore, histological healing was better in the omentum and omentum + PRP-treated groups than the control group (p = 0.001). The use of a decellularized omentum scaffold is suitable in the healing of critical bone defects.en_US
dc.identifier.citationEmet, A., Özdemir, E., Çetinkaya, D. U., Kılıç, E., Hashemihesar, R., Yürüker, A. C. S., & Turhan, E. (18 Nov 2021). Effect of a Decellularized Omentum Scaffold with Combination of Mesenchymal Stem Cells and Platelet-Rich Plasma on Healing of Critical-Sized Bone Defect: A Rat Model. Applied Sciences, 11(22), pp. 1-10. https://doi.org/10.3390/app112210900en_US
dc.identifier.doi10.3390/app112210900en_US
dc.identifier.endpage10en_US
dc.identifier.issue22en_US
dc.identifier.scopus2-s2.0-85119825642en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/app112210900
dc.identifier.urihttps://hdl.handle.net/20.500.13055/69
dc.identifier.volume11en_US
dc.identifier.wosWOS:000724743300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorHashemihesar, Ramin
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofApplied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSegmental bone defecten_US
dc.subjectPRPen_US
dc.subjectOmentumen_US
dc.subjectScaffolden_US
dc.subjectMesenchymal stem cellen_US
dc.titleEffect of a decellularized omentum scaffold with combination of mesenchymal stem cells and platelet-rich plasma on healing of critical-sized bone defect: A rat modelen_US
dc.typeArticleen_US
dspace.entity.typePublication

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