Effect of a decellularized omentum scaffold with combination of mesenchymal stem cells and platelet-rich plasma on healing of critical-sized bone defect: A rat model
dc.authorid | 0000-0003-3055-8518 | en_US |
dc.authorscopusid | 57219307968 | en_US |
dc.authorwosid | AAD-9922-2021 | en_US |
dc.contributor.author | Emet, Abdulsamet | |
dc.contributor.author | Özdemir, Erdi | |
dc.contributor.author | Uçkan Çetinkaya, Duygu | |
dc.contributor.author | Kılıç, Emine | |
dc.contributor.author | Hashemihesar, Ramin | |
dc.contributor.author | Yürüker, Ali Celalettin Sinan | |
dc.contributor.author | Turhan, Egemen | |
dc.date.accessioned | 2021-12-07T06:18:57Z | |
dc.date.available | 2021-12-07T06:18:57Z | |
dc.date.issued | 2021 | en_US |
dc.department | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.description.abstract | The high costs and extensive time needed for the treatment of critical-sized bone defects are still major clinical concerns in orthopedic surgery; therefore, researchers continue to look for more cost and time-effective methods. This study aims to investigate the effects of a decellularized omentum scaffold with a combination of platelet-rich plasma (PRP) and mesenchymal stem cells on the healing of critical-sized bone defects. Wistar albino rats (n = 30) were investigated in five groups. Critical-sized bone defects were formed on bilateral radius shafts. No scaffold, decellularized omentum, omentum with PRP and omentum + mesenchymal stem cells was used in group 1 (control group), 2, 3 and 4, respectively. In addition, omentum with a combination of mesenchymal stem cells +PRP was used in group 5. After 6 weeks, both radiological and histological healing were evaluated comparatively among the groups. After the use of a decellularized omentum scaffold, vitality of new cells was maintained, and new bone formation occurred. When compared to the control group, radiological healing was significantly better (p = 0.047) in the omentum and omentum + PRP-treated groups. Furthermore, histological healing was better in the omentum and omentum + PRP-treated groups than the control group (p = 0.001). The use of a decellularized omentum scaffold is suitable in the healing of critical bone defects. | en_US |
dc.identifier.citation | Emet, A., Özdemir, E., Çetinkaya, D. U., Kılıç, E., Hashemihesar, R., Yürüker, A. C. S., & Turhan, E. (18 Nov 2021). Effect of a Decellularized Omentum Scaffold with Combination of Mesenchymal Stem Cells and Platelet-Rich Plasma on Healing of Critical-Sized Bone Defect: A Rat Model. Applied Sciences, 11(22), pp. 1-10. https://doi.org/10.3390/app112210900 | en_US |
dc.identifier.doi | 10.3390/app112210900 | en_US |
dc.identifier.endpage | 10 | en_US |
dc.identifier.issue | 22 | en_US |
dc.identifier.scopus | 2-s2.0-85119825642 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 1 | en_US |
dc.identifier.uri | https://doi.org/10.3390/app112210900 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13055/69 | |
dc.identifier.volume | 11 | en_US |
dc.identifier.wos | WOS:000724743300001 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak.other | SCI-E - Science Citation Index Expanded | en_US |
dc.institutionauthor | Hashemihesar, Ramin | |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Applied Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Segmental bone defect | en_US |
dc.subject | PRP | en_US |
dc.subject | Omentum | en_US |
dc.subject | Scaffold | en_US |
dc.subject | Mesenchymal stem cell | en_US |
dc.title | Effect of a decellularized omentum scaffold with combination of mesenchymal stem cells and platelet-rich plasma on healing of critical-sized bone defect: A rat model | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication |
Dosyalar
Orijinal paket
1 - 1 / 1
Yükleniyor...
- İsim:
- Effect of a Decellularized Omentum Scaffold.pdf
- Boyut:
- 13.82 MB
- Biçim:
- Adobe Portable Document Format
- Açıklama:
- Tam Metin / Full Text
Lisans paketi
1 - 1 / 1
Kapalı Erişim
- İsim:
- license.txt
- Boyut:
- 1.44 KB
- Biçim:
- Item-specific license agreed upon to submission
- Açıklama: