Feeding the mind: Preliminary insights into the effects of anthocyanin-rich extract from black carrots on brain activity and gut microbiota in patients with cognitive impairments

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dc.authorid0000-0001-8552-4994
dc.authorid0000-0001-6304-2556
dc.authorid0009-0009-6984-0386
dc.authorid0000-0002-7373-4641
dc.authorid0009-0009-7765-6124
dc.authorid0000-0002-7855-7779
dc.authorid0000-0002-3629-7788
dc.contributor.authorMüdüroğlu Kırmızıbekmez, Aynur
dc.contributor.authorÖnder, Alparslan
dc.contributor.authorÖzdemir, Mustafa Yasir
dc.contributor.authorGürerk, Gamze
dc.contributor.authorAydın, Sevcan
dc.contributor.authorEryiğit, Önder Yüksel
dc.contributor.authorGüloğlu, Mehmet Oktar
dc.contributor.authorKara, İhsan
dc.date.accessioned2026-01-20T12:34:34Z
dc.date.available2026-01-20T12:34:34Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractAnthocyanins, known for their antioxidant and anti-inflammatory properties, have been associated with cognitive benefits, potentially mediated by gut-brain axis interactions. This study investigates the effects of a 12-week Anthocyanin-Rich Extract (ARE) intervention on brain activity and gut microbiota composition in older adults with neurocognitive impairments. In this study, 50 participants underwent electroencephalography (EEG) recordings and gut microbiota analyses before and after the intervention. EEG data were analyzed using connectivity and entropy metrics across multiple frequency bands. Gut microbiota composition was assessed via 16S rRNA sequencing to evaluate taxonomic shifts. Results revealed increased EEG connectivity, particularly in alpha, beta, and gamma frequency bands, suggesting improved neural communication and complexity following ARE consumption. Significant changes in nonlinear EEG metrics were observed, consistent with previous findings in the literature. Microbiota analysis indicated non-significant alterations in overall diversity but revealed increases in Alistipes, Streptococcus thermophilus, and Flavonifractor, alongside a decrease in Hungatella, potentially implicating SCFA metabolism and inflammatory regulation. These findings suggest ARE may enhance cognitive health by modulating neural activity and gut microbiota composition. While these results provide preliminary evidence of neuroprotective effects, further research with larger, disorder-specific cohorts and placebo-controlled designs is necessary to validate outcomes and explore gut-brain axis mechanisms in cognitive decline.
dc.identifier.citationMüdüroğlu Kırmızıbekmez, A., Önder, A., Özdemir, M. Y., Gürerk, G., Aydın, S., Eryiğit, Ö. Y., Güloğlu, M. O., & Kara, İ. (2025). Feeding the mind: Preliminary insights into the effects of anthocyanin-rich extract from black carrots on brain activity and gut microbiota in patients with cognitive impairments. Scientific Reports, 15(1), pp. 1-24. https://doi.org/10.1038/s41598-025-29256-z
dc.identifier.doi10.1038/s41598-025-29256-z
dc.identifier.endpage24
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmidPMID: 41310168
dc.identifier.scopus2-s2.0-105026412572
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1038/s41598-025-29256-z
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1251
dc.identifier.volume15
dc.identifier.wosWOS:001651055400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorEryiğit, Önder Yüksel
dc.institutionauthorid0000-0002-7855-7779
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnthocyanin
dc.subjectCognitive Impairments
dc.subjectGut-Brain Axis
dc.subjectEEG
dc.subjectMicrobiota
dc.titleFeeding the mind: Preliminary insights into the effects of anthocyanin-rich extract from black carrots on brain activity and gut microbiota in patients with cognitive impairments
dc.typeArticle
dspace.entity.typePublication

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