Small molecule influenza virus fusion inhibitors targeting viral hemagglutinin: Chemical insights and antiviral evaluation

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dc.authorid0000-0002-0309-663X
dc.authorid0009-0000-9667-4509
dc.authorid0000-0003-0516-6010
dc.contributor.authorÇınar, Gözde
dc.contributor.authorTekin, Mahmut Can
dc.contributor.authorCihan Üstündağ, Gökçe
dc.date.accessioned2025-10-15T14:06:38Z
dc.date.available2025-10-15T14:06:38Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractInfluenza viruses are major human pathogens that cause widespread respiratory infec tions, affecting millions of people globally and contributing to significant morbidity and mortality. Several currently available anti-influenza drugs are facing increasing levels of viral resistance. Therefore, the discovery of therapeutics targeting novel mechanisms of action is becoming increas ingly important. A key viral protein involved in the infection process is the envelope glycoprotein Hemagglutinin (HA), which facilitates both host cell receptor binding and membrane fusion, two essential steps required for viral entry and replication. Due to its central role in the early stages of infection, HA has emerged as a highly promising target for antiviral drug development. Many small molecule HA inhibitors have been identified with potential anti-influenza activity by stabilizing the HA structure and preventing its conformational change during the membrane fusion process. This review presents a detailed chemical evaluation of these HA-targeting compounds based on studies reported in the literature, highlighting their core chemical scaffolds and structural features. The antiviral efficacy of these compounds is discussed based on in vitro and in vivo data, along with insights into their mechanisms of action. A comprehensive literature search was conducted, and studies meeting the predefined inclusion criteria were thoroughly reviewed. By focusing on the chemical structure of these inhibitors, this review provides information for the rational design of new therapeutic agents aimed at preventing or limiting influenza virus infections.
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Grant Number: THZ-2024-41094). Bu çalışma, İstanbul Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından desteklenmiştir (Hibe Numarası: THZ-2024-41094).
dc.identifier.citationÇınar, G., Tekin, M. C., & Cihan Üstündağ, G. (2025). Small molecule influenza virus fusion inhibitors targeting viral hemagglutinin: Chemical insights and antiviral evaluation. Mini-Reviews in Medicinal Chemistry, pp. 1-11. https://doi.org/10.2174/0113895575401074250923075239
dc.identifier.doi10.2174/0113895575401074250923075239
dc.identifier.endpage11
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.2174/0113895575401074250923075239
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1137
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÇınar, Gözde
dc.institutionauthorid0000-0002-0309-663X
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofMini-Reviews in Medicinal Chemistry
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInfluenza Virus
dc.subjectAntiviral Evaluation
dc.subjectAnti-Influenza
dc.subjectHemagglutinin
dc.subjectPolyphenols
dc.subjectZanamivir
dc.titleSmall molecule influenza virus fusion inhibitors targeting viral hemagglutinin: Chemical insights and antiviral evaluation
dc.typeReview Article
dspace.entity.typePublication

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