The impact of conventional chemotherapy regimens and targeted drugs on ovarian function in breast cancer patients

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dc.authorid0000-0002-6697-8533
dc.authorid0009-0007-9968-5116
dc.authorid0000-0002-5855-9056
dc.authorid0000-0002-4803-7043
dc.authorid0000-0002-7596-2381
dc.authorid0000-0003-0582-5848
dc.authorid0000-0003-2287-799X
dc.authorid0000-0003-1966-3886
dc.contributor.authorHasköylü, Şeyma
dc.contributor.authorŞahin, Şevval Berfin
dc.contributor.authorAltıntaş, Alara
dc.contributor.authorYıldız, Şule
dc.contributor.authorBildik, Gamze
dc.contributor.authorBenlioğlu, Can
dc.contributor.authorTuran, Volkan
dc.contributor.authorKim, Samuel
dc.contributor.authorÖktem, Özgür
dc.date.accessioned2026-04-13T07:38:07Z
dc.date.available2026-04-13T07:38:07Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractBreast cancer is the most common malignancy among women, affecting nearly 1.5 million individuals worldwide every year. While survival rates improve, many reproductive-age survivors confront significant long-term consequences, particu larly diminished ovarian reserve, infertility, and premature ovarian insufficiency due to the gonadotoxic effects of chemo therapy. Postponement of pregnancy for five years or more after treatment exacerbates the decline in fertility due to ongo ing ovarian aging and depletion of residual ovarian reserve. Women carrying BRCA1/2 mutations may already exhibit reduced ovarian reserve and are more vulnerable to gonadal damage, possibly due to impaired DNA repair mechanisms associated with these mutations. The contribution of other breast cancer susceptibility genes (e.g., ATM, CHEK2, PALB2, BARD1, RAD51C, RAD51D, and TP53) to chemotherapy-induced gonadotoxicity remains unclear. Although animal data shows depletion of primordial follicle pool and granulosa cells dysfunction, the ovarian effects of the poly(ADP-ribose) polymerase (PARP) inhibitors in women with and without BRCA mutation are not clear. Immune-check point inhibi tors (ICIs) causes immune-mediated destruction of the primordial follicle pool and reduction in ovarian reserve. Cyclin dependent kinase inhibitors appear to be less toxic than ICIs. In this narrative review of the current literature we aimed to provide a comprehensive overview of the molecular mechanisms underlying ovarian toxicity associated with conventional chemotherapy and targeted therapies in breast cancer treatment.
dc.description.sponsorshipOpen access funding provided by the Scientific and Tech nological Research Council of Türkiye (TÜBİTAK). Bu çalışma için Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK) tarafından sağlanan açık erişim fonu kullanılmıştır.
dc.identifier.citationHasköylü, Ş., Şahin, Ş. B., Altıntaş, A., Yıldız, Ş., Bildik, G., Benlioğlu, C., Turan, V., Kim, S., & Öktem, Ö. (2026). The impact of conventional chemotherapy regimens and targeted drugs on ovarian function in breast cancer patients. Reproductive Sciences, https://doi.org/10.1007/s43032-026-02067-x
dc.identifier.doi10.1007/s43032-026-02067-x
dc.identifier.issn1933-7205
dc.identifier.pmidPMID: 41772301
dc.identifier.scopus2-s2.0-105031955053
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s43032-026-02067-x
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1395
dc.identifier.wosWOS:001704908800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTuran, Volkan
dc.institutionauthorid0000-0003-2287-799X
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofReproductive Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Cancer
dc.subjectOvarian Reserve
dc.subjectChemotherapy
dc.subjectPARP Inhibitors
dc.subjectImmune Check Point Inhibitors
dc.subjectCyclin Dependent Kinase Inhibitors
dc.subjectAmenorrhea
dc.subjectOvarian Function
dc.titleThe impact of conventional chemotherapy regimens and targeted drugs on ovarian function in breast cancer patients
dc.typeReview Article
dspace.entity.typePublication

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