Development of brimonidine-loaded ethosomes for glaucoma: Investigation of intraocular pressure-lowering potential in vivo

Basit Öğe Kaydı
dc.authorid0000-0001-6212-2706
dc.authorid0000-0002-6960-6364
dc.authorid0009-0000-3535-4915
dc.authorid0000-0002-4224-7453
dc.authorid0000-0001-5724-9809
dc.authorid0000-0002-7952-1241
dc.authorid0000-0002-9110-3704
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorSağıroğlu, Ali Asram
dc.contributor.authorŞen, Eslim
dc.contributor.authorGelmez Yıldız, Büşra
dc.contributor.authorKarimli, Laman
dc.contributor.authorEzgi Durgun, Meltem
dc.contributor.authorÇelebi, Ali Riza Cenk
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2026-02-13T08:36:19Z
dc.date.available2026-02-13T08:36:19Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractBackground/Objectives: Brimonidine tartrate (BRT), a selective α2-adrenergic receptor agonist, is commonly used in the treatment of glaucoma. However, conventional eye drop formulations suffer from poor ocular bioavailability and rapid elimination. This study aimed to develop and evaluate BRT-loaded ethosomes as a nanocarrier-based alternative to enhance intraocular delivery and therapeutic efficacy. Methods: Ethosomes were prepared using the thin-film hydration method and optimized via central composite design. The optimized formulation was subjected to physicochemical characterization, in vitro release testing, and ocular irritation assessment using the Hen egg test—chorioallantoic membrane (HET-CAM) model. Additionally, the intraocular pressure (IOP)-lowering efficacy of the formulation was evaluated in a rat glaucoma model. Results: The optimized ethosomal formulation exhibited favorable physicochemical properties, including a mean particle size of 122.6 ± 0.7 nm, zeta potential of −1.8 ± 0.9 mV, and encapsulation efficiency of 87.33 ± 0.04%. In vitro release data followed Higuchi kinetics. HET-CAM analysis indicated non-irritancy. In vivo, the ethosomal BRT formulation achieved comparable IOP-lowering effects to the marketed eye drops at one-third of the dose. Conclusions: The developed BRT loaded ethosomal system demonstrated promising physicochemical stability, sustained release, and therapeutic potential. These findings suggest that ethosomes may offer a safe and effective strategy for enhancing the ocular delivery of BRT in glaucoma therapy.
dc.description.sponsorshipThe project was granted internal research funding from Acibadem University Scientific Research Projects Coordination Unit (Project number: THD-2024-2211) which provides a budget that covers the expense of in vivo study. Proje, Acıbadem Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi'nden (Proje numarası: THD-2024-2211) iç araştırma fonu almıştır ve bu fon, in vivo çalışmanın masraflarını karşılayacak bir bütçe sağlamaktadır.
dc.identifier.citationÖzdemir, S., Sağıroğlu, A. A., Şen, E., Gelmez Yıldız, B., Karimli, L., Ezgi Durgun, M., Çelebi, A. R. C., & Özsoy, Y. (2026). Development of brimonidine-loaded ethosomes for glaucoma: Investigation of intraocular pressure-lowering potential in vivo. Pharmaceutics, 18(2), pp. 1-26. https://doi.org/10.3390/pharmaceutics18020210
dc.identifier.doi10.3390/pharmaceutics18020210
dc.identifier.endpage26
dc.identifier.issn1999-4923
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics18020210
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1328
dc.identifier.volume18
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖzdemir, Samet
dc.institutionauthorEzgi Durgun, Meltem
dc.institutionauthorid0000-0001-6212-2706
dc.institutionauthorid0000-0001-5724-9809
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofPharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBrimonidine Tartrate
dc.subjectEthosomes
dc.subjectHET-CAM
dc.subjectIntraocular Pressure
dc.subjectGlaucoma
dc.subjectOphthalmic Drug Delivery
dc.titleDevelopment of brimonidine-loaded ethosomes for glaucoma: Investigation of intraocular pressure-lowering potential in vivo
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text.pdf
Boyut:
2.62 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Farmasötik Teknoloji Ana Bilim Dalı Koleksiyonu