Investigation of volumetric alterations in thalamic subnuclei in progressive and stable mild cognitive impairment using magnetic resonance imaging

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dc.authorid0000-0002-8329-5507
dc.authorid0000-0003-4520-3955
dc.contributor.authorHarı, Emre
dc.contributor.authorSoylu, Can
dc.date.accessioned2026-06-06T11:55:11Z
dc.date.available2026-06-06T11:55:11Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective: This study aimed to evaluate the volumes of thalamic subnuclei known to function in large-scale cognitive networks between progressive mild cognitive impairment (pMCI) and stable MCI (sMCI) groups progressing to dementia. Materials and Methods: Magnetic resonance imaging and clinical data of 31 pMCI (Age: 68.66±6.86; education: 15.71±2.46; gender: 15 female) and 31 sMCI (Age: 70.18±7.24; education: 16.23±2.68; gender: 13 female) patients with no statistically significant differences in age, gender, education, and follow-up interval (mean 21 months) from the Alzheimer's Disease Neuroimaging Initiative database were used. FreeSurfer software was used for individual thalamus segmentation and volume calculation. Thalamic nuclei were divided into anterior, medial, posterior, lateral, ventral, and intralaminar nucleus groups. The volumes of each nucleus were normalised using intracranial volume. Normalised volumes were compared between groups using independent samples t-test, and false discovery rate (FDR) correction was applied. Correlation analysis was performed using florbetapir (AV45) PET scores to evaluate the relationship between amyloid burden in the brain and volumetric decrease. Results: Statistically significant volumetric decreases were detected in the bilateral anterior (Right: t=2.432 pFDR=0.048; Left: t=2.327 pFDR=0.048) and lateral (t=2.372 pFDR=0.048) nucleus groups in pMCI compared to sMCI. A negative correlation was found between PET scores and bilateral anterior nucleus groups (Right: r=-0.353 p=0.026, left: r=-0.350 p=0.026). Conclusion: In our study, the anterior thalamic nucleus group, closely associated with memory, showed reduced volume in MCI patients who progressed to dementia, and this reduction correlated with amyloid burden in the brain. Based on the findings of our study, the anterior thalamic nucleus group may provide supportive value to other MRI biomarkers in predicting conversion to dementia.
dc.description.sponsorshipThis work was supported by Istanbul University Research University Support Program (Grant #: TSA-2022-39128). Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). Authors of this study were supported in part by National Institutes of Health grants NIA 2 P01 AG03949, NIA 1R01AG039409–01, NIA R03 AG045474, NIH K01AG054700, the Leonard and Sylvia Marx Foundation, and the Czap Foundation Bu çalışma, İstanbul Üniversitesi Araştırma Destek Programı (Burs No: TSA-2022-39128) tarafından desteklenmiştir. Bu proje için veri toplama ve paylaşımı, Alzheimer Hastalığı Nörogörüntüleme Girişimi (ADNI) (Ulusal Sağlık Enstitüleri Bursu U01 AG024904) ve DOD ADNI (Savunma Bakanlığı ödül numarası W81XWH-12-2-0012) tarafından finanse edilmiştir. Bu çalışmanın yazarları kısmen Ulusal Sağlık Enstitüleri bursları NIA 2 P01 AG03949, NIA 1R01AG039409–01, NIA R03 AG045474, NIH K01AG054700, Leonard ve Sylvia Marx Vakfı ve Czap Vakfı tarafından desteklenmiştir.
dc.identifier.citationHarı, E., & Soylu, C. (2026). Investigation of volumetric alterations in thalamic subnuclei in progressive and stable mild cognitive impairment using magnetic resonance imaging. Journal of İstanbul Faculty of Medicine, 89(2), pp. 104-109. https://doi.org/10.26650/IUITFD.1747544
dc.identifier.doi10.26650/IUITFD.1747544
dc.identifier.endpage109
dc.identifier.issn1305-6441
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105038943786
dc.identifier.scopusqualityQ3
dc.identifier.startpage104
dc.identifier.urihttps://doi.org/10.26650/IUITFD.1747544
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1507
dc.identifier.volume89
dc.identifier.wosWOS:001775597000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorSoylu, Can
dc.institutionauthorid0000-0003-4520-3955
dc.language.isoen
dc.publisherİstanbul University Press
dc.relation.ispartofJournal of İstanbul Faculty of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThalamus
dc.subjectMild Cognitive Impairment
dc.subjectMagnetic Resonance Imaging
dc.subjectDementia
dc.subjectVolumetric Analysis
dc.titleInvestigation of volumetric alterations in thalamic subnuclei in progressive and stable mild cognitive impairment using magnetic resonance imaging
dc.typeArticle
dspace.entity.typePublication

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