Development of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taras Shevchenko National University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study presents a simple, rapid, and accurate spectrophotometric method for the determination of Aripiprazole (ARP) in tablets. The determination procedure is based on the reaction of ARP with 7,7,8,8-tet racyanoquinodimethane (TCNQ), producing a colored product that was quantitated spectrophotometrically at 392 nm. Various variables affecting the reaction were optimized. The method exhibited a good linearity range with a correlation coefficient of 0.9994, observed as 0.25–3 μg/mL. The developed method was validated according to the International Council for Harmonisation (ICH) guidelines, assessing specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), and limit of quantitation (LOQ). The formation of the CT-complex and the interaction sites were confirmed by elemental analysis, DSC, IR, and 1H NMR spectroscopy. The method was successfully applied to the determination of ARP in pharmaceutical preparation.
Açıklama
Anahtar Kelimeler
Schizophrenia, Antipsychotics, Aripiprazole, Spectrophotometric Method, Pharmaceutical Preparations
Kaynak
Methods and Objects of Chemical Analysis
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
19
Sayı
4
Künye
Dinçel, D., Bahadori, F., Kepekçi Tekkeli, Ş. E., & Önal, A. (2024). Development of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications. Methods and Objects of Chemical Analysis, 19(4), pp. 219-225. http://doi.org/10.17721/moca.2024.219-225
