Development of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications

Basit Öğe Kaydı
dc.authorid0000-0001-8319-9307
dc.authorid0000-0003-4224-9309
dc.authorid0000-0002-1871-017X
dc.authorid0000-0001-8455-1173
dc.contributor.authorDinçel, Demet
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.contributor.authorÖnal, Armağan
dc.date.accessioned2025-02-09T09:03:27Z
dc.date.available2025-02-09T09:03:27Z
dc.date.issued2024
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractThis study presents a simple, rapid, and accurate spectrophotometric method for the determination of Aripiprazole (ARP) in tablets. The determination procedure is based on the reaction of ARP with 7,7,8,8-tet racyanoquinodimethane (TCNQ), producing a colored product that was quantitated spectrophotometrically at 392 nm. Various variables affecting the reaction were optimized. The method exhibited a good linearity range with a correlation coefficient of 0.9994, observed as 0.25–3 μg/mL. The developed method was validated according to the International Council for Harmonisation (ICH) guidelines, assessing specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), and limit of quantitation (LOQ). The formation of the CT-complex and the interaction sites were confirmed by elemental analysis, DSC, IR, and 1H NMR spectroscopy. The method was successfully applied to the determination of ARP in pharmaceutical preparation.
dc.identifier.citationDinçel, D., Bahadori, F., Kepekçi Tekkeli, Ş. E., & Önal, A. (2024). Development of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications. Methods and Objects of Chemical Analysis, 19(4), pp. 219-225. http://doi.org/10.17721/moca.2024.219-225
dc.identifier.doi10.17721/moca.2024.219-225
dc.identifier.endpage225
dc.identifier.issn2413-6166
dc.identifier.issn1991-0290
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85215104628
dc.identifier.scopusqualityQ4
dc.identifier.startpage219
dc.identifier.urihttp://doi.org/10.17721/moca.2024.219-225
dc.identifier.urihttps://hdl.handle.net/20.500.13055/914
dc.identifier.volume19
dc.identifier.wosWOS:001416617500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorKepekçi Tekkeli, Şerife Evrim
dc.institutionauthorid0000-0002-1871-017X
dc.language.isoen
dc.publisherTaras Shevchenko National University
dc.relation.ispartofMethods and Objects of Chemical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchizophrenia
dc.subjectAntipsychotics
dc.subjectAripiprazole
dc.subjectSpectrophotometric Method
dc.subjectPharmaceutical Preparations
dc.titleDevelopment of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
727.08 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Analitik Kimya Ana Bilim Dalı Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu