Smart thermoresponsive sol–gel formulation of polyhexanide for rapid and painless burn and wound management

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dc.authorid0000-0003-0113-6850
dc.authorid0000-0002-6803-494X
dc.authorid0000-0002-6502-528X
dc.authorid0000-0002-8431-1230
dc.authorid0000-0001-6212-2706
dc.contributor.authorAlparslan, Levent
dc.contributor.authorTorkay, Gülşah
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorKöksal Karayıldırım, Çinel
dc.contributor.authorÖzdemir, Samet
dc.date.accessioned2025-08-20T15:52:46Z
dc.date.available2025-08-20T15:52:46Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractTraditional wound and burn treatments often fall short in balancing antimicrobial efficacy, patient comfort, and ease of application. This study introduces a novel, transparent, ther moresponsive sol–gel formulation incorporating polyhexamethylene biguanide (PHMB) for advanced topical therapy. Utilizing Poloxamer 407 as a biocompatible carrier, the formulation remains a sprayable liquid at room temperature and instantly gels upon contact with body temperature, enabling painless, pressure-free application on sensitive, injured skin. Comprehensive in vitro and in vivo evaluations confirmed the formulation’s broad-spectrum antimicrobial efficacy (≥5 log10 reduction in 30 s), high biocompatibility (viability > 70% in fibroblasts), non-irritancy (OECD 425-compliant), and physical stabil ity across three months. Importantly, the formulation maintained fibroblast migration capacity—crucial for wound regeneration—while exhibiting rapid sol-to-gel transition at ~34 ◦C. These findings highlight the system’s potential as a next-generation wound dressing with enhanced user compliance, transparent monitoring capability, and rapid healing support, particularly in disaster or emergency scenarios.
dc.identifier.citationAlparslan, L., Torkay, G., Bal Öztürk, A., Köksal Karayıldırım, Ç., & Özdemir, S. (2025). Smart thermoresponsive sol–gel formulation of polyhexanide for rapid and painless burn and wound management. Polymers, 17(15), pp. 1-18. https://doi.org/10.3390/polym17152079
dc.identifier.doi10.3390/polym17152079
dc.identifier.endpage18
dc.identifier.issn2073-4360
dc.identifier.issue15
dc.identifier.pmidPMID: 40808127
dc.identifier.scopus2-s2.0-105013345443
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/polym17152079
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1083
dc.identifier.volume17
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖzdemir, Samet
dc.institutionauthorid0000-0001-6212-2706
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofPolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiseptic
dc.subjectBurn Care
dc.subjectPoloxamer 407
dc.subjectPolyhexanide
dc.subjectSol–Gel
dc.subjectThermoreversible Gel
dc.subjectWound Treatment
dc.titleSmart thermoresponsive sol–gel formulation of polyhexanide for rapid and painless burn and wound management
dc.typeArticle
dspace.entity.typePublication

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