Design and characterization of dexamethasone loaded microsponges for the management of ulcerative colitis

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorÜner, Burcu
dc.contributor.authorBaranauskaite, Juste
dc.contributor.authorSümer, Engin
dc.contributor.authorYıldırım, Ecem
dc.contributor.authorYaba, Aylin
dc.date.accessioned2023-04-17T07:17:31Z
dc.date.available2023-04-17T07:17:31Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractUlcerative colitis is an inflammatory condition with ulcerations throughout the colon. The existing remedies have some limitations such as drug inactivation, poor absorption, and adverse reactions. The present study aimed to design novel microsponge formulations to enhance remission of the dexamethasone (as a model pharmaceutical ingredient) in the colon. Microsponges were prepared by using the quasi-emulsion technique. The optimal formulation was selected by applying the design of experiments approach which used methylcellulose (MC) (0.75–2%, w/w), polyvinylalcohol (PVA)(0.5–1%, w/w), and tween 80 (TW80) (1.5–2.5%, w/w). The critical quality attributes were selected as particle size and entrapment efficiency. The particle size and encapsulation efficiency were found as 140.38 ± 9.2 µm and 77.96 ± 3.4 %. After the optimization; morphological, thermal, and physicochemical characterization studies were performed. Ultimately, the optimal formulation was investigated by using the acetic acid-induced ulcerative colitis model in rats. The physicochemical characterization studies confirmed that the formulation components were compatible with each other. The in vitro release mechanisms were fitted to First order kinetics at pH 1.2 (R2:0.9563), and Korsmeyer-Peppas kinetics at pH 4.5 (R2: 0.9877), and pH 6.8 (R2: 0.9706). The medicated microsponges exhibited remarkable recovery compared to the control group of the in vivo ulcerative colitis model (p < 0.05). It could be concluded that microsponges were evaluated as a promising alternative drug delivery system for the management of ulcerative colitis.en_US
dc.identifier.citationÖzdemir, S., Üner, B., Baranauskaite, J., Sümer, E., Yıldırım, E., & Yaba, A. (2023). Design and characterization of dexamethasone loaded microsponges for the management of ulcerative colitis. European Journal of Pharmaceutics and Biopharmaceutics, 187, pp. 34-45. https://doi.org/10.1016/j.ejpb.2023.04.007en_US
dc.identifier.doi10.1016/j.ejpb.2023.04.007en_US
dc.identifier.endpage45en_US
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.pmidPMID: 37061099en_US
dc.identifier.scopus2-s2.0-85152438091en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpb.2023.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.13055/445
dc.identifier.volume187en_US
dc.identifier.wosWOS:000985225800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrospongesen_US
dc.subjectDexamethasoneen_US
dc.subjectUlcerative Colitisen_US
dc.subjectBioavailabilityen_US
dc.subjectDesign of Experimentsen_US
dc.titleDesign and characterization of dexamethasone loaded microsponges for the management of ulcerative colitisen_US
dc.typeArticleen_US
dspace.entity.typePublication

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