Age-adjusted associations between routine systemic inflammatory markers and anti-müllerian hormone in reproductive-age women: A retrospective cross-sectional study

Basit Öğe Kaydı
dc.authorid0000-0002-6814-6212
dc.authorid0000-0003-1052-5911
dc.authorid0000-0002-0335-2330
dc.authorid0000-0002-1311-6892
dc.authorid0000-0002-9438-6113
dc.authorid0000-0002-6424-7411
dc.contributor.authorKaralök, Mete Hakan
dc.contributor.authorDündar, Bağnu
dc.contributor.authorParmaksız, Ayhan
dc.contributor.authorElgün, Tuğba
dc.contributor.authorGündoğan, Gül İpek
dc.contributor.authorGök Yurttaş, Asiye
dc.date.accessioned2026-08-21T15:56:41Z
dc.date.available2026-08-21T15:56:41Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractBackground: Anti-Müllerian hormone (AMH) is widely used as a marker of ovarian reserve and is strongly influenced by chronological age. Although inflammation has been implicated in ovarian aging and follicular dysfunction, whether routinely measured peripheral inflammatory markers provide additional information regarding AMH concentrations remains unclear. Objective: This study aimed to evaluate the age-adjusted associations of C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR) with serum AMH concentrations in reproductive-age women. Methods: This retrospective cross-sectional study included women aged 18–45 years with available AMH, complete blood count, and CRP measurements. After reapplying the prespecified eligibility criteria and excluding confirmed data-entry or analytical errors, 819 women were included in the final analysis. NLR was calculated from absolute neutrophil and lymphocyte counts. Because CRP and NLR showed right-skewed distributions, Box–Cox transformations were applied. Associations with Box–Cox-transformed AMH were evaluated using an age-adjusted left-censored Tobit regression model. Results: The mean age of the participants was 34.07 ± 6.94 years, and the median AMH concentration was 1.07 ng/mL (interquartile range, 0.29–2.50). Chronological age was inversely associated with AMH (β = −0.123, 95% CI: −0.135 to −0.111, p < 0.001). After adjustment for age, neither CRP (β = −0.038, 95% CI: −0.085 to 0.009, p = 0.114) nor NLR (β = −0.012, 95% CI: −0.222 to 0.198, p = 0.912) was independently associated with AMH. Conclusions: In this retrospective outpatient cohort, routine peripheral inflammatory markers did not explain additional variation in AMH beyond chronological age. These results do not exclude a potential role for local ovarian inflammation, which may not be adequately captured by peripheral CRP or NLR measurements.
dc.description.sponsorshipThis research received institutional support from Istanbul Atlas University. No specific external funding was received for this study. Bu araştırma İstanbul Atlas Üniversitesi'nin kurumsal desteğiyle gerçekleştirilmiştir. Bu çalışma için herhangi bir dış finansman desteği alınmamıştır.
dc.identifier.citationKaralök, M. H., Dündar, B., Parmaksız, A., Elgün, T., Gündoğan, G. İ., & Gök Yurttaş, A. (2026). Age-adjusted associations between routine systemic inflammatory markers and anti-müllerian hormone in reproductive-age women: A retrospective cross-sectional study. Biomedicines, 14(8), pp. 1-14. https://doi.org/10.3390/biomedicines14081733
dc.identifier.doi10.3390/biomedicines14081733
dc.identifier.endpage14
dc.identifier.issn2227-9059
dc.identifier.issue8
dc.identifier.pmidPMID: 42652116
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/biomedicines14081733
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1594
dc.identifier.volume14
dc.identifier.wosWOS:001859975500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorParmaksız, Ayhan
dc.institutionauthorid0000-0002-0335-2330
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofBiomedicines
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Müllerian Hormone
dc.subjectOvarian Reserve
dc.subjectReproductive Age
dc.subjectNeutrophil-To Lymphocyte Ratio
dc.subjectC-Reactive Protein
dc.subjectNucleated Red Blood Cells
dc.subjectSystemic Inflammation
dc.subjectTobit Regression
dc.titleAge-adjusted associations between routine systemic inflammatory markers and anti-müllerian hormone in reproductive-age women: A retrospective cross-sectional study
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text.pdf
Boyut:
1.77 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu