Hemimyelomeningocele: A systematic review and meta‑analysis of the literature

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dc.authorid0000-0002-4284-8611
dc.authorid0009-0001-3875-6319
dc.authorid0009-0006-3265-1950
dc.authorid0009-0005-9386-5779
dc.authorid0009-0000-9846-0360
dc.authorid0009-0007-1169-5003
dc.authorid0000-0002-3036-0061
dc.contributor.authorAdıyaman, Ali Ekrem
dc.contributor.authorKarakaş, Furkan
dc.contributor.authorHamzaoğlu, Can
dc.contributor.authorSaban, Şevval
dc.contributor.authorKılınç, Tunahan
dc.contributor.authorAcar, Burak
dc.contributor.authorNabili, Tabriz
dc.contributor.authorEkşi, Murat Şakir
dc.date.accessioned2026-02-10T07:15:07Z
dc.date.available2026-02-10T07:15:07Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractHemimyelomeningocele (HMM) is a rare split cord malformation where only one hemicord forms a myelomeningocele-like sac, and the opposite hemicord undergoes normal neurulation. We aimed to compile all published HMM cases to concisely summarize embryology, presentation, imaging, associated anomalies, management, and outcomes of the disorder. Following PRISMA 2020, we searched PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar (1968–Feb 2025) for studies with confirmed human HMM, extracting clinical, radiological, surgical, and follow-up data. Of 688 records screened, 25 articles met inclusion criteria, encompassing 67 patients. Most publications were single-patient case reports. Presentation occurred predominantly in newborns or early infancy. The dysraphic sac was lumbosacral in most cases, and type I split cord malformation with a bony spur outnumbered type II. Hemivertebrae and congenital scoliosis were the common vertebrae anomalies. Nearly all patients underwent surgery combining sac excision, detethering, and bony spur removal. Postopera tive neurological outcomes were favorable: the majority improved, and the other ones remained stable; no surgery-related mortality was reported. HMM can be recognized as a distinct clinic radiological entity within the split-cord spectrum. Early, ideally prenatal diagnosis, timely microsurgical repair, and coordinated multidisciplinary care yield favorable functional outcomes in most patients. This first systematic review compiles the available evidence and provides a practical basis for future diagnostic and treatment decisions.
dc.identifier.citationAdıyaman, A. E., Karakaş, F., Hamzaoğlu, C., Saban, Ş., Kılınç, T., Acar, B., Nabili, T., & Ekşi, M. Ş. (2026). Hemimyelomeningocele: A systematic review and meta‑analysis of the literature. Child's Nervous System, 42(1), pp. 1-16. https://doi.org/10.1007/s00381-025-07122-7
dc.identifier.doi10.1007/s00381-025-07122-7
dc.identifier.endpage16
dc.identifier.issn1433-0350
dc.identifier.issn0256-7040
dc.identifier.issue1
dc.identifier.pmidPMID: 41511579
dc.identifier.scopus2-s2.0-105026976932
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s00381-025-07122-7
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1308
dc.identifier.volume42
dc.identifier.wosWOS:001658774400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAcar, Burak
dc.institutionauthorid0009-0000-9846-0360
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofChild's Nervous System
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHemimyelomeningocele
dc.subjectHemimeningomyelocele
dc.subjectSplit Cord Malformation
dc.subjectDiastematomyelia
dc.subjectSpinal Dysraphism
dc.subjectMyelomeningocele
dc.titleHemimyelomeningocele: A systematic review and meta‑analysis of the literature
dc.typeReview Article
dspace.entity.typePublication

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