The inhibitory effect of betulinic acid on epithelial-mesenchymal transition pathway in renal cell carcinoma

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dc.authorid0000-0003-3465-180en_US
dc.authorscopusid57198446979en_US
dc.authorwosidS-9157-2017en_US
dc.contributor.authorAtaş, Merve Nur
dc.contributor.authorErtuğrul, Barış
dc.contributor.authorİplik, Elif Sinem
dc.contributor.authorÇakmakoğlu, Bedia
dc.contributor.authorErgen, Arzu
dc.date.accessioned2022-11-10T13:54:52Z
dc.date.available2022-11-10T13:54:52Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractRenal cancer is the most lethal urological cancer and characterized by high metastasis rate at initial diagnosis and drug resistance to current chemotherapeutics. Betulinic acid is a pentacyclic triterpene with broad biological activity that occurs naturally in variety of plants. Even though the anti-cancer efficacy of betulinic acid have been reported by many studies, the information about the pathways and the molecules which are affected by betulinic acid in renal cancer are limited. Epithelial-mesenchymal transition (EMT) is considered as the initial step of metastasis and contributes to drug resistance of cancer cells. Depending on the role of EMT in cancer progression and drug resistance, targeting EMT may represent an effective strategy in this context. Therefore, we aimed to investigate the anti-metastatic effects of betulinic acid on renal cell carcinoma cells by evaluating two EMT markers, SNAIL-1, and SDC-2. Following the treatment of betulinic acid at determined doses by WST-1 cytotoxicity assay in our previous study, SDC-2 expression level was decreased in both cell lines. Additionally, in correlation with this result, we also found a reduction in SDC-2 and SNAIL-1 protein levels which are measured by ELISA. Furthermore, the migration and invasion capacities were suppressed by betulinic acid treatment in metastatic renal adenocarcinoma ACHN cells. Taken together, our findings indicate that betulinic acid may constitute a potential treatment approach for renal cancer with further investigations.en_US
dc.description.sponsorshipIstanbul University--TSA-2019-35150en_US
dc.identifier.citationAtaş, M. N., Ertuğrul, B., İplik, E. S., Çakmakoğlu, B. & Ergen, A. (2022). The inhibitory effect of betulinic acid on epithelial-mesenchymal transition pathway in renal cell carcinoma. Medical Oncology, 39(11), 1-7. https://doi.org/10.1007/s12032-022-01775-zen_US
dc.identifier.doi10.1007/s12032-022-01775-zen_US
dc.identifier.endpage7en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue11en_US
dc.identifier.pmidPMID: 35972672en_US
dc.identifier.scopus2-s2.0-85136093961en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-022-01775-z
dc.identifier.urihttps://hdl.handle.net/20.500.13055/300
dc.identifier.volume39en_US
dc.identifier.wosWOS:000841289400014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorİplik, Elif Sinem
dc.language.isoenen_US
dc.publisherHumana Pressen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBetulinic Aciden_US
dc.subjectPentacyclic Triterpeneen_US
dc.subjectRenal Canceren_US
dc.subjectEpithelial-Mesenchymal Transitionen_US
dc.subjectCell Lineen_US
dc.titleThe inhibitory effect of betulinic acid on epithelial-mesenchymal transition pathway in renal cell carcinomaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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