Nicotinic acid–modified chitosan nanoparticles for enhanced resveratrol delivery and anticancer activity

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dc.authorid0000-0002-3052-4556
dc.authorid0000-0002-9127-2380
dc.authorid0000-0003-2185-2619
dc.authorid0000-0001-5269-1067
dc.authorid0000-0003-2497-9359
dc.contributor.authorŞentürk, Sema
dc.contributor.authorKaplan, Özlem
dc.contributor.authorBal, Kevser
dc.contributor.authorKüçükertuğrul Çelik, Sibel
dc.contributor.authorGökşen Tosun, Nazan
dc.contributor.authorGök, Mehmet Koray
dc.date.accessioned2026-04-05T13:03:40Z
dc.date.available2026-04-05T13:03:40Z
dc.date.issued2026
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThis study focused on functionalizing chitosan with nicotinic acid, the active form of vitamin B3, to obtain a new derivative (ChiNico) with enhanced solubility at physiological pH, improved proton buffering capacity, and in vitro anticancer activity, and to develop resveratrol-loaded nanoparticles (nChiNico-RES) for enhanced anticancer performance. Chitosan was modified through EDC-mediated amidation, and successful conjugation was confirmed by FTIR, 1H NMR, and GPC/SEC analyses. Nicotinic acid grafting increased molecular weight, introduced characteristic amide signals, improved solubility at physiological pH, and enhanced proton buffering capacity. Nanoparticles were prepared by ionotropic gelation and showed sizes of 100–140nm, PDI values below 0.4, and a positive surface charge of +18 to +20mV. Blank nanoparticles exhibited minimal cytotoxicity, while resveratrol-loaded formulations demonstrated significant anticancer activity in HeLa cervical cancer cells and HT-29 human colon adenocarcinoma cell line. Notably, nChiNico-RES reduced HeLa and HT-29 cell viability more effectively than free resver atrol and nanoparticles based on unmodified chitosan, indicating an additive contribution from nicotinic acid. In contrast, the cytotoxic effect on healthy BJ fibroblasts remained considerably lower, supporting the biocompatibility and selective potential of the system. Overall, nicotinic acid modification improves chitosan's carrier performance and offers a novel strategy by combin ing two natural bioactive molecules within a single nanoparticle platform.
dc.description.sponsorshipThis was supported by the project DPT-2019K12-149071 funded by the Presidency of the Republic of Türkiye, Strategy and Budget Office. Bu çalışma, Türkiye Cumhuriyeti Cumhurbaşkanlığı Strateji ve Bütçe Ofisi tarafından finanse edilen DPT-2019K12-149071 numaralı proje kapsamında desteklenmiştir.
dc.identifier.citationŞentürk, S., Kaplan, Ö., Bal, K., Küçükertuğrul Çelik, S., Gökşen Tosun, N., & Gök, M. K. (2026). Nicotinic acid–modified chitosan nanoparticles for enhanced resveratrol delivery and anticancer activity. Biopolymers, 117(2), pp. 1-13. https://doi.org/10.1002/bip.70085
dc.identifier.doi10.1002/bip.70085
dc.identifier.endpage13
dc.identifier.issn1097-0282
dc.identifier.issue2
dc.identifier.pmidPMID: 41699981
dc.identifier.scopus2-s2.0-105030262543
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/bip.70085
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1386
dc.identifier.volume117
dc.identifier.wosWOS:001716454700009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorŞentürk, Sema
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiopolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer Therapy
dc.subjectChitosan
dc.subjectDrug Delivery
dc.subjectNicotinic Acid
dc.subjectResveratrol
dc.titleNicotinic acid–modified chitosan nanoparticles for enhanced resveratrol delivery and anticancer activity
dc.typeArticle
dspace.entity.typePublication

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