Mast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotonin

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dc.authorid0000-0002-6516-3201en_US
dc.authorscopusid6507583495en_US
dc.authorwosidAAT-5652-2020en_US
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTöre, Fatma
dc.date.accessioned2021-12-10T14:11:41Z
dc.date.available2021-12-10T14:11:41Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractNeuroinflammation plays a key role in the pathogenesis of epilepsy, but the underlying mechanisms are not well understood. Mast cells are multifunctional immune cells that are also activated by stress. The effects of activated mast cells on epileptogenesis are not yet known. This study investigated the effects and mechanisms of compound 48/80-stimulated mast cell activation on pentylenetetrazole-induced epileptic seizures in rats. Male Wistar rats were separated into seven groups (n = 12). Group-1(NS+PTZ) received intraperitoneal saline solution, while groups 2(C-48/80+PTZ-1), 3(C-48/80+PTZ-2), and 4(C-48/80+PTZ-3) received compound-48/80 at doses of 0.5, 1, and 2 mg/kg, respectively, 30 min before 45 mg/kg pentylenetetrazole administration. Similarly, Group-5(Cr+C-48/80+PTZ) received 10 mg/kg cromolyn plus 2 mg/kg compound-48/80 before pentylenetetrazole, and Group-6(MC Dep+C-48/80+PTZ) was exposed to a mast cell-depletion process, and then received 2 mg/kg compound-48/80. Group-7(5-HT+PTZ) received 10 mg/kg serotonin. Seizure stages were evaluated using Racine's scale. Compound-48/80 at 2 mg/kg induced anticonvulsive effects against pentylenetetrazole-induced seizures by extending onset-times of both myoclonic-jerk and generalized tonic-clonic seizures (p = 0.0001), and by shortening the duration of generalized tonic-clonic seizure (p = 0.008). These effects were reversed by cromolyn (p = 0.0001). These effects were not observed in mast cell-depleted rats. Similarly to compound 48/80, serotonin also exhibited anticonvulsive effects against seizures (p < 0.05). Compound 48/80 acts as an anticonvulsant by activating mast cells in a dose-dependent manner. The anticonvulsive effects of mast cell activation may be mediated by serotonin. Mast cell activation may therefore provide protective activity against seizures under appropriate circumstances.en_US
dc.identifier.citationKılınç, E., Torun, I. E., Çetinkaya, A., & Töre, F. (2021). Mast cell activation ameliorates pentylenetetrazole‐induced seizures in rats: The potential role for serotonin. European Journal of Neuroscience, 55(9-10), 2912–2924. https://doi.org/10.1111/ejn.15145en_US
dc.identifier.doi10.1111/ejn.15145en_US
dc.identifier.endpage2924en_US
dc.identifier.issue9-10en_US
dc.identifier.pmidPMID: 33565644en_US
dc.identifier.scopus2-s2.0-85101275894en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2912en_US
dc.identifier.urihttps://doi.org/10.1111/ejn.15145
dc.identifier.urihttps://hdl.handle.net/20.500.13055/80
dc.identifier.volume55en_US
dc.identifier.wosWOS:000620646300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpileptic Seizuresen_US
dc.subjectMast Cellsen_US
dc.subjectModerate Stressen_US
dc.subjectNeuroinflammationen_US
dc.subjectSerotoninen_US
dc.titleMast cell activation ameliorates pentylenetetrazole-induced seizures in rats: The potential role for serotoninen_US
dc.typeArticleen_US
dspace.entity.typePublication

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