Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity

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dc.authorid0000-0003-2378-1535
dc.authorid0000-0002-1720-9711
dc.authorid0000-0002-1338-0087
dc.authorid0000-0002-5697-9217
dc.authorid0000-0002-9453-100X
dc.authorid0000-0002-4059-1760
dc.authorid0000-0003-1272-5845
dc.contributor.authorHasanoğlu Sayın, Sevde
dc.contributor.authorKandemir, İbrahim
dc.contributor.authorOyacı, Yasemin
dc.contributor.authorKhudiyeva, Shahri
dc.contributor.authorŞahin, Memduh
dc.contributor.authorYetim Şahin, Aylin
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2025-09-26T14:05:05Z
dc.date.available2025-09-26T14:05:05Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: The present study aimed to investigate whether nitric oxide synthase (NOS) enzyme gene variants (iNOS rs1060826, eNOS rs1799983, eNOS 27-bp VNTR) play a role in the etiopathogenesis of nonalcoholic fatty liver (NAFLD) in adolescents. Methods: This cross-sectional study was conducted with obese adolescents [body mass index (BMI) standard devia tion score (SDS) ≥2] aged 10–19 years (104 individuals) and age- and sex-matched healthy individuals (64 individuals) whose presence of NAFLD was determined by ultrasound. The iNOS rs1060826 and eNOS rs1799983 variants were performed by Polymerase Chain Reaction-Restriction Frag ment Length Polymorphism (PCR-RFLP) method, and the eNOS 27-bp VNTR variant was analyzed using the PCR method. The genotypes detected were compared between the patient group and the healthy controls and with the clinical parameters of the patients. Results: iNOS rs1060826 and eNOS rs1799983 were inde pendent of obesity, whereas eNOS 27-bp VNTR was inde pendent of NAFLD. However, in the obese group, especially in those with NAFLD (+), the iNOS rs1060826 GG genotype was found to be associated with lower diastolic blood pres sure (DBP) (p=0.011). Compared with the clinical parameters, insulin resistance (HOMA-IR) was higher in those carrying the eNOS rs1799983 gene variant-TT genotype in the NAFLD (+) group (p=0.051). Conclusions: While the three functional gene variants of the NOS enzyme did not show a significant difference in terms of genotype between patients and healthy controls, it was determined that both the iNOS rs1060826 gene variant GG allele was associated with low DBP and HOMA-IR may be higher in those carrying the eNOS rs1799983 gene variant TT genotype in NAFLD (+) patients. The iNOS rs1060826 poly morphism is a potentially important genetic variant that may influence DBP regulation through its effects on nitric oxide production.
dc.identifier.citationHasanoğlu Sayın, S., Kandemir, İ., Oyacı, Y., Khudiyeva, S., Şahin, M., Yetim Şahin, A., & Pehlivan, S. (2025). Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity. Journal of Pediatric Endocrinology and Metabolism, pp. 1-10. https://doi.org/10.1515/jpem-2025-0229
dc.identifier.doi10.1515/jpem-2025-0229
dc.identifier.endpage10
dc.identifier.issn2191-0251
dc.identifier.issn0334-018X
dc.identifier.pmidPMID: 40960128
dc.identifier.scopus2-s2.0-105016364841
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1515/jpem-2025-0229
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1122
dc.identifier.wosWOS:001572505100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherDe Gruyter
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectObesity
dc.subjectGenetics
dc.subjectNASH
dc.subjectLiver
dc.subjectNitric Oxide
dc.titleInvestigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity
dc.typeArticle
dspace.entity.typePublication

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