Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant

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dc.authorid0000-0002-1720-9711
dc.authorid0000-0002-1338-0087
dc.authorid0000-0002-4059-1760
dc.authorid0000-0002-5697-9217
dc.authorid0000-0002-9453-100X
dc.authorid0000-0001-5394-1566
dc.authorid0000-0002-6692-085X
dc.authorid0000-0001-9689-4464
dc.authorid0000-0003-1272-5845
dc.contributor.authorKandemir, İbrahim
dc.contributor.authorYetim Şahin, Aylin
dc.contributor.authorOyacı, Yasemin
dc.contributor.authorKhudiyeva, Shahri
dc.contributor.authorŞahin, Memduh
dc.contributor.authorAksakal, Melike Tuğrul
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorBaş, Firdevs
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2024-10-31T10:05:58Z
dc.date.available2024-10-31T10:05:58Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIt is known that telomere length (TL) (evaluated with T/S ratio) is shortened in the presence of obesity. In this study, we aimed to investigate how obesity in adolescents and non-alcoholic liver disease (NAFLD) within the obese group affect TL and the clinical significance of the human telomerase reverse transcriptase (hTERT) gene MNS16A VNTR variant in terms of NAFLD. Adolescents with exogenous obesity and healthy controls (aged 10-19 years) who applied to our adolescent outpatient clinic between May-October 2023 were included in this study. We performed upper abdominal ultrasonography to investigate the presence of NAFLD in adolescents with obesity and divided into two groups: those without hepatosteatosis (obese NAFLD (-)) and those with hepatosteatosis (obese NAFLD (+)). We recorded body weight, height, waist circumference, and blood pressure measurements and measured the T/S ratio (telomere sequence copy number/gene single copy number) by the Quantitative Polymerase Chain Reaction method. The groups were compared using frequentist and Bayesian methods. Eighty-three obese adolescents [63 NAFLD(+) 20 NAFLD(-)] and 69 lean controls were included in the study. Pairwise comparisons revealed that T/S ratio was significantly lower in the obese NAFLD (-) group than the obese NAFLD (+) and the control group (p = 0.025, p = 0.007, respectively). T/S ratio was lower in the LL allele group than in the other alleles (p = 0.022) and slightly higher in the obese group with metabolic syndrome compared to the obese group without metabolic syndrome (p = 0.072). hTERT-MNS16A-VNTR gene variant LL allele had a negative correlation with T/S ratio among the obese adolescent group. Patients with LL alleles had higher ALT, GGT, HOMA-IR, and ALT/AST. Diastolic blood pressure had a significant correlation with the T/S ratio. The T/S ratio was shorter in the obese adolescent group compared to healthy ones but was higher in the NAFLD (+) obese compared to the NAFLD (-) obese. ALT level and ALT/AST ratio were higher, T/S ratio was lower in the hTERT MNS16A VNTR variant LL allele group among obese adolescents. In addition, there was a significant correlation between the T/S ratio and diastolic blood pressure in obese adolescents.
dc.identifier.citationKandemir, İ., Yetim Şahin, A., Oyacı, Y., Khudiyeva, S., Şahin, M., Aksakal, M. T., Pehlivan, M., Baş, F., & Pehlivan, S. (2024). Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant. Scientific Reports, 14(1), pp. 1-9. https://doi.org/10.1038/s41598-024-77091-5
dc.identifier.doi10.1038/s41598-024-77091-5
dc.identifier.endpage9
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmidPMID: 39443618
dc.identifier.scopus2-s2.0-85207465900
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1038/s41598-024-77091-5
dc.identifier.urihttps://hdl.handle.net/20.500.13055/839
dc.identifier.volume14
dc.identifier.wosWOS:001341352800134
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMetabolic Syndrome
dc.subjectNAFLD
dc.subjectObese Adolescents
dc.subjectTelomere Length
dc.subjectHtert-MNS16A-VNTR Gene
dc.titleEffect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant
dc.typeArticle
dspace.entity.typePublication

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