Synergistic and dose-dependent effects of pinostrobin, pinocembrin and pinobanksin on different breast cancer cell lines

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dc.authorid0000-0002-3635-8421en_US
dc.authorscopusid57194783843en_US
dc.authorwosidDVP-7029-2022en_US
dc.contributor.authorMelekoğlu, Abdullah
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorEronat, Allison Pınar
dc.contributor.authorÖztürk, Tülin
dc.contributor.authorPehlevan, Funda
dc.contributor.authorYılmaz-Aydoğan, Hülya
dc.contributor.authorÖztürk, Oğuz
dc.date.accessioned2023-12-21T17:40:24Z
dc.date.available2023-12-21T17:40:24Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalıen_US
dc.description.abstractIn this study, the cytotoxic and apoptotic effects of three phenolic compounds highly found in the poplar type propolis; pinostrobin (PS), pinocembrin (PC) and pinobanksin (PB), were investigated individually and in combination on hormon-positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines and fibrocystic breast epithelium (MCF-10A) as control. Assessment of cytotoxicity and apoptosis were performed with WST-1 and Annexin V-7AAD assays, respectively. All statistical analyses including the two-way ANOVA and multiple-t-test were performed using GraphPad Prism software. Individually, PB (P<0.0001), PS (P<0.0001), and PC (P<0.05) demonstrated potent cytotoxic effects at moderate to high doses and late time intervals on MCF-7. PB and PS have been found to have a significant proliferative effect at low doses (P<0.0001), however, this effect disappeared in higher doses in this cell line. Dual combinations of PB+PC and PB+PS were toxic on MCF-10A, however, dual combination of PS+PC and the triple combination (PB+PS+PC) showed no cytotoxicity until high doses at late time intervals (P>0.05). On MCF-7, the triple combination induced cytotoxic/apoptotic effects even with the 25% dose and 50% dose on MDA-MB-231(p<0.0001). Our findings clearly showed that different combinations of these phenolic substances can have synergistic cytotoxic effects and even hormetic effects in non-tumorogenic cells.en_US
dc.description.sponsorshipThis study was funded by the Scientific Projects Coordination Unit, Istanbul University (Project No. 24695 and 29818).en_US
dc.identifier.citationMelekoğlu, A., Ceviz, A. B., Eronat, A. P., Öztürk, T., Pehlevan, F., Yılmaz-Aydoğan, H., & Öztürk, O. (2024). Synergistic and dose-dependent effects of pinostrobin, pinocembrin and pinobanksin on different breast cancer cell lines. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 30(1), pp. 23-30. https://doi.org/10.9775/kvfd.2023.30187en_US
dc.identifier.doi10.9775/kvfd.2023.30187en_US
dc.identifier.endpage30en_US
dc.identifier.issn1309-2251
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85179667174en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2023.30187
dc.identifier.urihttps://hdl.handle.net/20.500.13055/603
dc.identifier.volume30en_US
dc.identifier.wosWOS:001127310300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorCeviz, Ayşe Begüm
dc.language.isoenen_US
dc.publisherKafkas Üniversitesien_US
dc.relation.ispartofKafkas Üniversitesi Veteriner Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Cancer Cell Lineen_US
dc.subjectCytotoxicityen_US
dc.subjectPinobanksinen_US
dc.subjectPinocembrinen_US
dc.subjectPinostrobinen_US
dc.subjectPropolisen_US
dc.titleSynergistic and dose-dependent effects of pinostrobin, pinocembrin and pinobanksin on different breast cancer cell linesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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