Fluid biomarkers in atypical Parkinsonism: Current state and future perspectives

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dc.authorid0000-0003-3006-8711
dc.authorid0000-0002-2216-3973
dc.authorid0000-0002-7394-7161
dc.authorid0000-0002-9193-3150
dc.authorid0000-0002-8584-5488
dc.contributor.authorBougea, Anastasia
dc.contributor.authorColosimo, Carlo
dc.contributor.authorFalup‑Pecurariu, Cristian
dc.contributor.authorPalermo, Giovanni
dc.contributor.authorDeğirmenci, Yıldız
dc.date.accessioned2025-05-25T13:17:04Z
dc.date.available2025-05-25T13:17:04Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractDiagnosing Atypical Parkinsonian Syndromes (APS) may be challenging due to overlapping clinical features of Parkinson’s disease (PD), and the lack of pathognomonic diagnostic tests. Fluid biomarkers can be useful tools that make it easier to identify and track diferent APS. Objectives: this narrative review aim to update the current state of fuid biomarker research in APS and their potential implications in clinical practice. A comprehensive literature search was conducted in PubMed and Scopus using the following terms: “Aβ42 amyloid beta with 42 amino acids’’, “ alpha-synuclein’’, “Atypical Parkinso nian Syndromes’’, “corticobasaldegeneration’’, “C reactive protein’’, “cerebrospinal fuid’’, “dementia with Lewy bodies’’, “multiple system atrophy’’, “neuroflament light, oligomericαsyn, phosphorylated α –syn’’, “tau phosphorylated at threonine 181’’, “progressive supranuclear palsy’’, “Seeding Amplifcation Assay’’, “t-tau; total tau”. The lack of high-afnity α-syn antibodies and ligands may contribute to α-syn’s low efcacy as a diagnostic biomarker of APS. Cerebrospinal fuid (CSF) biomarkers refecting Alzheimer pathology, axonal damage (neuroflament light chain) add valuable diagnostic and prog nostic information in the neurochemical characterization of APS. Infammatoryand microRNAs markers need to be further validated before their clinical use. Seeding Amplifcation Assays (SAA), despite their high sensitivity and specifcity, are at this point used only as a research tool, and they are not quantitative or refective of disease severity. Biomarker research for early identifcation and prognosis of APS patients requires multicenter collaboration, validation, and AI-based diagnostics, despite immature biological classifcation systems.
dc.identifier.citationBougea, A., Colosimo, C., Falup‑Pecurariu, C., Palermo, G., & Değirmenci, Y. (2025). Fluid biomarkers in atypical Parkinsonism: Current state and future perspectives. Journal of Neural Transmission, https://doi.org/10.1007/s00702-025-02930-2
dc.identifier.doi10.1007/s00702-025-02930-2
dc.identifier.issn1435-1463
dc.identifier.issn0300-9564
dc.identifier.pmid40392273
dc.identifier.scopus2-s2.0-105005784340
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00702-025-02930-2
dc.identifier.urihttps://hdl.handle.net/20.500.13055/990
dc.identifier.wosWOS:001491338900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorDeğirmenci, Yıldız
dc.institutionauthorid0000-0002-8584-5488
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofJournal of Neural Transmission
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtypical Parkinsonian Syndromes (APS)
dc.subjectBiomarkers
dc.subjectCorticobasal Degeneration (CBD)
dc.subjectDementia With Lewy Bodies (DLB)
dc.subjectMultiple System Atrophy (MSA)
dc.subjectProgressive Supranuclear Palsy
dc.titleFluid biomarkers in atypical Parkinsonism: Current state and future perspectives
dc.typeArticle
dspace.entity.typePublication

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