New insights of cerium oxide nanoparticles in head and neck cancer treatment

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dc.authorid0000-0003-3739-4683
dc.authorid0000-0003-3979-9182
dc.authorid0000-0001-5871-8486
dc.authorid0000-0002-2742-6058
dc.authorid0000-0001-9041-8408
dc.authorid0000-0002-2265-2283
dc.authorid0000-0001-7549-8040
dc.authorid0000-0002-0766-768X
dc.authorid0000-0002-8919-0482
dc.authorid0000-0001-8646-0363
dc.contributor.authorTarakçı, Elif
dc.contributor.authorEsmkhani, Sahra
dc.contributor.authorBayramova, Jamila
dc.contributor.authorBilgin, Feride Melisa
dc.contributor.authorKıdık, Kübra
dc.contributor.authorAdıgüzel, Şevin
dc.contributor.authorTufan, Yiğithan
dc.contributor.authorYılmaz, Ahsen Morva
dc.contributor.authorYazıcı, Hülya
dc.contributor.authorDuygulu, Özgür
dc.date.accessioned2025-03-25T06:54:23Z
dc.date.available2025-03-25T06:54:23Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractHead and neck cancer (HNC) is a genetically complex cancer type having treatment difficulties due to affecting multiple organs in complex anatomical sites. Radiotherapy resistance, chemotoxicity, post-surgery disability makes HNC treatment more complicated. Therefore, there is need to developed new treatment approaches. Nanoparticle-based therapies especially cerium oxide nanoparticles with its anti-cancer features, high catalytic activity, anti- or pro-oxidant and radio-protective properties give a boon for HNC treatment. In the current study, two dextran-coated cerium oxide nanoparticles (Dex-CeNPs) namely SD1 and SD2 were synthesized and characterized by using two types of dextran (D1 and D2) having distinct molecular weights and branching characteristics to understand their potential as a new HNC treatment strategy while evaluating the role of dextran type. The effectivity of the SD1 and SD2 on the HNC cell lines (A253, SCC-25, FaDu) were investigated by analyzing their cytotoxicity, genotoxicity, reactive oxygen species (ROS) generation properties. Low IC50 value, high ROS generation and stability profiling of SD2 compared to SD1 indicates the distinct function of dextran type on Dex-CeNPs effectivity on HNC. To better elucidate the effectivity of SD2, flow cytometry analysis and pro-apoptotic (TP53, CASP3, BAX) and anti-apoptotic (Bcl-2) gene expression profiling were investigated in detail. The findings indicate that SD2 exhibits an influence on head and neck cancer cells via the apoptotic pathway. Our research sets the framework for the development of Dex-CeNPs as remarkable nanotherapeutic candidates for treatment of head and neck cancer.
dc.identifier.citationTarakçı, E., Esmkhani, S., Bayramova, J., Bilgin, F. M., Kıdık, K., Adıgüzel, Ş., Tufan, Y., Yılmaz, A. M., Yazıcı, H., & Duygulu, Ö. (2025). New insights of cerium oxide nanoparticles in head and neck cancer treatment. Scientific Reports, 15, pp. 1-18. https://doi.org/10.1038/s41598-025-85228-3
dc.identifier.doi10.1038/s41598-025-85228-3
dc.identifier.endpage18
dc.identifier.issn2045-2322
dc.identifier.pmidPMID: 40044797
dc.identifier.scopus2-s2.0-86000059351
dc.identifier.scopus2-s2.0-86000059351
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1038/s41598-025-85228-3
dc.identifier.urihttps://hdl.handle.net/20.500.13055/939
dc.identifier.volume15
dc.identifier.wosqualityQ1
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorYazıcı, Hülya
dc.institutionauthorid0000-0002-8919-0482
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak113G100
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerium Oxide Nanoparticle
dc.subjectDextran Coated Nanoceria
dc.subjectNanotherapeutics
dc.subjectHead and Neck Cancer
dc.titleNew insights of cerium oxide nanoparticles in head and neck cancer treatment
dc.typeArticle
dspace.entity.typePublication

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