Noncontrast-enhanced MRI-based noninvasive score for portal hypertension (CHESS1802): An international multicenter study

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dc.authorid0000-0002-8909-2102en_US
dc.authorscopusid56035868800en_US
dc.authorwosidAAU-7657-2020en_US
dc.contributor.authorLiu, Yanna
dc.contributor.authorTang, Tianyu
dc.contributor.authorÖrmeci, Necati
dc.contributor.authorHuang, Yifei
dc.contributor.authorWang, Jitao
dc.contributor.authorLi, Xiaoguo
dc.contributor.authorLi, Zhiwei
dc.contributor.authorAn, Weimin
dc.contributor.authorLiu, Dengxiang
dc.contributor.authorZhang, Chunqing
dc.contributor.authorLiu, Changchun
dc.contributor.authorLiu, Jinqiang
dc.contributor.authorLiu, Chuan
dc.contributor.authorWang, Guangchuan
dc.contributor.authorMosconi, Cristina
dc.contributor.authorCappelli, Alberta
dc.contributor.authorBruno, Antonio
dc.contributor.authorAkçalar, Seray
dc.contributor.authorÇelebioğlu, Emrecan
dc.contributor.authorÜstüner, Evren
dc.contributor.authorBilgiç, Sadık
dc.contributor.authorEllik, Zeynep
dc.contributor.authorAsiller, Özgün Ömer
dc.date.accessioned2021-12-22T11:32:14Z
dc.date.available2021-12-22T11:32:14Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground and Aims This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hypertension in cirrhosis. Methods In this international multicenter, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with cirrhosis who had hepatic venous pressure gradient (HVPG) measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China (n=4) and Turkey (n=1) between December 2018 and April 2019. A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity. Results A total of 149 patients were included, of which 124 were from four Chinese hospitals (training cohort) and 25 were from two international hospitals (validation cohort). A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36 (p<0.0001) and 0.55 (p<0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respectively. The intraclass correlation coefficients for assessing the inter- and intra-observer agreement were 0.846 and 0.841, respectively. Conclusions A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG. Besides, this score could be used to detect CSPH in patients with cirrhosis.en_US
dc.identifier.citationLiu, Y., Tang, T., Örmeci, N., Huang, Y., Wang, J., Li, X., Li, Z., An, W., Liu, D., Zhang, C., Liu, C., Liu, J., Liu, C., Wang, G., Mosconi, C., Cappelli, A., Bruno, A., Akçalar, S., Çelebioğlu, E., … Qi, X. (2021). Noncontrast-enhanced MRI-based noninvasive score for portal hypertension (CHESS1802): An international multicenter study. Journal of Clinical and Translational Hepatology, 9(6), pp. 818-827. https://doi.org/10.14218/JCTH.2021.00177en_US
dc.identifier.doi10.14218/JCTH.2021.00177en_US
dc.identifier.endpage827en_US
dc.identifier.issue6en_US
dc.identifier.pmidPMID: 34966645en_US
dc.identifier.scopus2-s2.0-8512198782en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage818en_US
dc.identifier.urihttps://doi.org/10.14218/JCTH.2021.00177
dc.identifier.urihttps://hdl.handle.net/20.500.13055/105
dc.identifier.volume9en_US
dc.identifier.wosWOS:000702548100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖrmeci, Necati
dc.language.isoenen_US
dc.publisherXia & He Publishing Inc.en_US
dc.relation.ispartofJournal of Clinical and Translational Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver Cirrhosisen_US
dc.subjectAdvanced Chronic Liver Diseaseen_US
dc.subjectHepatic Venous Pressure Gradienten_US
dc.subjectLiver Surface Nodularityen_US
dc.subjectImagingen_US
dc.titleNoncontrast-enhanced MRI-based noninvasive score for portal hypertension (CHESS1802): An international multicenter studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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