Red cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants

Basit Öğe Kaydı
dc.authorid0000-0002-4834-9127
dc.authorid0000-0002-1720-9711
dc.contributor.authorArcagök, Baran Cengiz
dc.contributor.authorKandemir, İbrahim
dc.date.accessioned2025-09-16T10:50:45Z
dc.date.available2025-09-16T10:50:45Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/Objectives: Bronchopulmonary dysplasia (BPD) frequently affects preterm infants and is associated with lasting morbidity. Early prediction remains challenging. The present study investigated whether hematological inflammatory markers—platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and red cell distribution width-to-platelet ratio (RPR)—can predict the development of BPD in preterm neonates. Methods: We performed a retrospective cohort study involving 100 infants born at less than 32 weeks’ gestation. Complete blood count (CBC) parameters were collected at birth, 72 h, 1 week, and 2 weeks of life. Associations between PLR, RDW, RPR, and BPD development were analyzed. Multivariate regression and receiver operating characteristic (ROC) curve analyses were carried out to evaluate the predictive performance of the markers. Results: Forty-nine percent of infants developed BPD. Those with BPD had significantly higher RDW, PLR, and RPR values, and lower lymphocyte and platelet counts at various time points. Gestational age, respiratory distress syndrome, and hematological indices independently predicted BPD. ROC analysis showed that RDW ≥ 67.2 and PLR ≥ 98.13 at 72 h, and RPR ≥ 0.3 at 7 and 14 days had good predictive performance. A combined scoring system, including clinical and hematological markers, achieved high sensitivity and specificity. Conclusions: Hematological inflammatory markers, especially RPR, PLR, and RDW, derived from routine CBC tests may serve as accessible, cost-effective tools for early BPD risk stratification in preterm infants. Additional studies are needed to confirm these results and better define their relevance in clinical practice.
dc.identifier.citationArcagök, B. C., & Kandemir, İ. (2025). Red cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants. Children, 12(9), pp. 1-14. https://doi.org/10.3390/children12091215
dc.identifier.doi10.3390/children12091215
dc.identifier.endpage14
dc.identifier.issn2227-9067
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/children12091215
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1111
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorKandemir, İbrahim
dc.institutionauthorid0000-0002-1720-9711
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofChildren
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBronchopulmonary Dysplasia
dc.subjectPreterm Infants Platelet-To-Lymphocyte Ratio
dc.subjectRDW-To-Platelet Ratio
dc.subjectInflammatory Biomarkers
dc.titleRed cell distribution width-to-platelet ratio and other hematological markers as early predictors of bronchopulmonary dysplasia in preterm infants
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text
Boyut:
523.33 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Dahili Tıp Bilimleri Bölümü Koleksiyonu