Clinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: Findings from a multicentre cross sectional study

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dc.authorid0000-0003-0257-1061
dc.authorid0000-0003-3584-2788
dc.authorid0000-0001-8790-304X
dc.authorid0000-0002-1050-9666
dc.authorid0000-0002-3734-1242
dc.authorid0000-0002-0418-0155
dc.authorid0000-0001-6062-6935
dc.authorid0000-0003-3012-2968
dc.authorid0000-0001-7519-9470
dc.authorid0000-0003-1324-2108
dc.authorid0000-0003-3570-3825
dc.authorid0000-0002-9427-9529
dc.authorid0000-0003-2728-5934
dc.authorid0000-0002-0825-5169
dc.authorid0000-0001-7129-2109
dc.contributor.authorSarıyıldız, Emine
dc.contributor.authorDuruöz, Mehmet Tuncay
dc.contributor.authorGezer, Halise Hande
dc.contributor.authorAktaş, İlknur
dc.contributor.authorAkar, Servet
dc.contributor.authorHizmetli, Sami
dc.contributor.authorŞahin, Nilay
dc.contributor.authorAkgül, Özgür
dc.contributor.authorAlkan Melikoğlu, Meltem
dc.contributor.authorSezer, İlhan
dc.contributor.authorAtaman, Şebnem
dc.contributor.authorUral Nazlıkul, Fatma Gülçin
dc.contributor.authorÇapkın, Erhan
dc.contributor.authorYılmaz, Figen
dc.contributor.authorKalyoncu, Umut
dc.date.accessioned2025-11-24T16:10:58Z
dc.date.available2025-11-24T16:10:58Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı
dc.description.abstractPeripheral joint disease (PJD) is the most common peripheral manifestation in spondyloarthritis (SpA) patients. This study aimed to determine PJD characteristics and associated factors in patients with axial SpA (AxSpA) and peripheral SpA (pSpA). This cross-sectional and multicenter study involved 13 different rheumatology and physical medicine & reha bilitation clinics, and patients diagnosed with axSpA or pSpA were included in the study. PJD was defined as the ‘ever’ related to SpA according to the physician. Multivariable analyses were conducted to identify factors associated with PJD. A total of 394 patients were enrolled in the study (57.6% male, mean age 40.8 years), of whom 359 (91.1%) were clas sified as AxSpA and 35 (8.9%) as pSpA. Peripheral arthritis was reported in 118 patients (29.9%), comprising 85 (72%) with AxSpA and 33 (28%) with pSpA. Among the whole population with PJD, the main joint involvement pattern was monoarticular (33.9%, n=40) and oligoarticular (49.2%, n=58). The rate of predominantly lower limb and large joint involvement was approximately 60% (n=68) and the major course of PJD was transient (42.4%, n=50) and intermit tent (40.7%, n=48). pSpA patients had a higher rate of persistent (33.3% vs. 14.3%, p=0.021) and progressive arthritis (15.2% vs. 1.2%, p=0.007). The coexistence of PJD with other peripheral involvement and extra-articular manifestations excluding psoriasis was widespread. Dactylitis, enthesitis, and high CRP level were positively associated with PJD; on the contrary, ever alcohol intake, presence of sacroiliitis on MRI, and family history for SpA were negatively associated. PJD was accompanied by both other peripheral involvements and extra-articular manifestations, excluding psoriasis and the course of PJD was more persistent in pSpA patients. This undoubtedly contributes to an increased disease burden.
dc.identifier.citationSarıyıldız, E., Duruöz, M. T., Gezer, H. H., Aktaş, İ., Akar, S., Hizmetli, S., Şahin, N., Akgül, Ö., Alkan Melikoğlu, M., Sezer, İ., Ataman, Ş., Ural Nazlıkul, F. G., Çapkın, E., Yılmaz, F., & Kalyoncu, U. (2025). Clinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: Findings from a multicentre cross sectional study. Rheumatology International, 45(1), pp. 1-12. https://doi.org/10.1007/s00296-025-06021-z
dc.identifier.doi10.1007/s00296-025-06021-z
dc.identifier.endpage12
dc.identifier.issn1437-160X
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s00296-025-06021-z
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1204
dc.identifier.volume45
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorUral Nazlıkul, Fatma Gülçin
dc.institutionauthorid0000-0002-9427-9529
dc.language.isoen
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSpondyloarthritis
dc.subjectEnthesitis
dc.subjectDactylitis
dc.subjectArthritis
dc.subjectDisease Burden
dc.titleClinical characteristics of peripheral joint disease in axial and peripheral spondyloarthritis: Findings from a multicentre cross sectional study
dc.typeArticle
dspace.entity.typePublication

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