Stevioside improves brain oxidant-antioxidant status in overfed zebrafish

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dc.authorid0000-0002-4905-1912en_US
dc.authorscopusid57366604500en_US
dc.authorwosidGPS-5248-2022en_US
dc.contributor.authorDandin, Esra
dc.contributor.authorÜnal, İsmail
dc.contributor.authorBeler, Merih
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorCansız, Derya
dc.contributor.authorAteş Kalkan, Perihan Seda
dc.contributor.authorEmekli-Alturfan, Ebru
dc.date.accessioned2024-01-23T06:15:38Z
dc.date.available2024-01-23T06:15:38Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractObjective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world’s population suffers from obesity. Overnutrition is associated with the deterioration of mitochondrial functions in the brain in the case of obesity. In this study, we evaluated the effects of stevioside (ST) which is a calorie-free, naturally occurring herbal sweetener made from Stevia rebaudiana (Bertoni) on the oxidant-antioxidant balance in the brain in cases of overnutrition. Accordingly, the effects of ST consumption on the oxidant-antioxidant balance in the brain was evaluated and determined in a case study of overfeeding adult zebrafish for 15 days. Materials and Methods: Zebrafish were placed in four groups; the control group (C); overfed group (OF); low-dose (1mg/L) ST treated OF group (OF+LDS); and the high-dose ST (5mg/L) treated OF group (OF+HDS). The levels of lipid peroxidation (LPO) were evaluated together with nitric oxide (NO) to determine the oxidant status. The antioxidant status from the activities of the superoxide dismutase (SOD) and glutathione S-transferase (GST) were determined in brain tissues. Results: The ST treatment decreased the increased LPO and NO levels in overfed zebrafish and increased SOD and GST activities in a dose-dependent manner. Conclusion: ST exerted an antioxidant effect on the possible damage mechanisms that could occur in the brain in case of overnutrition by decreasing oxidative stress and improving the antioxidant enzyme activities.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Commission -- Grant number: SAG-C-YLP-100719-0263en_US
dc.identifier.citationDandin, E., Ünal, İ., Beler, M., Üstündağ, Ü. V., Cansız, D., Ateş Kalkan, P. S., & Emekli-Alturfan, E. (2023). Stevioside improves brain oxidant-antioxidant status in overfed zebrafish. European Journal of Biology, 82(2), pp. 258-262. https://doi.org/10.26650/EurJBiol.2023.1301847en_US
dc.identifier.doi10.26650/EurJBiol.2023.1301847en_US
dc.identifier.endpage262en_US
dc.identifier.issn2602-2575
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-8518222316en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage258en_US
dc.identifier.trdizinid1276752
dc.identifier.urihttps://doi.org/10.26650/EurJBiol.2023.1301847
dc.identifier.urihttps://hdl.handle.net/20.500.13055/637
dc.identifier.volume82en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAteş Kalkan, Perihan Seda
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofEuropean Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSteviosideen_US
dc.subjectOverfeedingen_US
dc.subjectBrainen_US
dc.subjectOxidant-Antioxidant Statusen_US
dc.subjectZebrafishen_US
dc.titleStevioside improves brain oxidant-antioxidant status in overfed zebrafishen_US
dc.typeArticleen_US
dspace.entity.typePublication

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