Stevioside improves brain oxidant-antioxidant status in overfed zebrafish
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Istanbul University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world’s population suffers from obesity. Overnutrition is associated with the deterioration of mitochondrial functions in the brain in the case of obesity. In this study, we evaluated the effects of stevioside (ST) which is a calorie-free, naturally occurring herbal sweetener made from Stevia rebaudiana (Bertoni) on the oxidant-antioxidant balance in the brain in cases of overnutrition. Accordingly, the effects of ST consumption on the oxidant-antioxidant balance in the brain was evaluated and determined in a case study of overfeeding adult zebrafish for 15 days. Materials and Methods: Zebrafish were placed in four groups; the control group (C); overfed group (OF); low-dose (1mg/L) ST treated OF group (OF+LDS); and the high-dose ST (5mg/L) treated OF group (OF+HDS). The levels of lipid peroxidation (LPO) were evaluated together with nitric oxide (NO) to determine the oxidant status. The antioxidant status from the activities of the superoxide dismutase (SOD) and glutathione S-transferase (GST) were determined in brain tissues. Results: The ST treatment decreased the increased LPO and NO levels in overfed zebrafish and increased SOD and GST activities in a dose-dependent manner. Conclusion: ST exerted an antioxidant effect on the possible damage mechanisms that could occur in the brain in case of overnutrition by decreasing oxidative stress and improving the antioxidant enzyme activities.
Açıklama
Anahtar Kelimeler
Stevioside, Overfeeding, Brain, Oxidant-Antioxidant Status, Zebrafish
Kaynak
European Journal of Biology
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
82
Sayı
2
Künye
Dandin, E., Ünal, İ., Beler, M., Üstündağ, Ü. V., Cansız, D., Ateş Kalkan, P. S., & Emekli-Alturfan, E. (2023). Stevioside improves brain oxidant-antioxidant status in overfed zebrafish. European Journal of Biology, 82(2), pp. 258-262. https://doi.org/10.26650/EurJBiol.2023.1301847
