Is neurodegeneration accelerated? Investigating covıd-19’s impact on dementia via functional connectivity

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dc.authorid0000-0001-8552-4994
dc.authorid0000-0001-6304-2556
dc.authorid0009-0009-6984-0386
dc.authorid0000-0002-7855-7779
dc.authorid0000-0002-3209-852X
dc.contributor.authorMüdüroğlu Kırmızıbekmez, Aynur
dc.contributor.authorÖnder, Alparslan
dc.contributor.authorÖzdemir, Mustafa Yasir
dc.contributor.authorEryiğit, Önder Yüksel
dc.contributor.authorYurdakoş, Ertan
dc.date.accessioned2025-09-01T08:52:26Z
dc.date.available2025-09-01T08:52:26Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractIntroduction: COVID-19 has been associated with various neurological complications, including cognitive impairments such as memory deficits, attention difficulties, and executive dysfunction. These symptoms raise concerns about potential long-term effects, particularly in individuals with preexisting neurodegenerative conditions. Emerging evidence suggests that systemic inflammation, blood-brain barrier (BBB) dysfunction, and neuroinflammation may contribute to cognitive decline in COVID-19 patients. However, the impact of COVID-19 on functional brain connectivity, particularly in dementia patients, remains unclear. This study aims to investigate the differences in functional connectivity across different frequency bands (delta, theta, alpha, beta, and gamma) in dementia patients with and without a history of COVID-19 (D-COVID and D-nCOVID) compared to a healthy control (HC) group. The study explores whether COVID-19 accelerates neurodegenerative processes by disrupting functional brain networks. Methods: Functional connectivity was assessed using electroencephalography (EEG)-based network analysis in three groups: D-COVID, D-nCOVID, and HC. Connectivity metrics were compared across frequency bands, with a focus on local efficiency (LE) and global network alterations. The Kruskal-Wallis test assessed statistical significance, while the Dunn test was used for post-hoc analysis. Results: Findings indicate a significant reduction in functional connectivity across multiple brain regions in dementia patients, with the D-COVID group exhibiting more pronounced declines. The observed decrease in connectivity suggests that COVID-19 may accelerate neurodegenerative processes. Additionally, the HC group demonstrated stronger connectivity and higher LE metrics, highlighting the widespread impact of dementia on brain networks. Conclusion: These findings support the hypothesis that COVID-19 contributes to cognitive decline by exacerbating neurodegenerative mechanisms. The disruption of functional brain connectivity observed in D-COVID patients aligns with previous studies suggesting that SARS-CoV-2 may indirectly promote neuronal degeneration. Further longitudinal studies are needed to determine the long-term cognitive consequences of COVID-19 and potential therapeutic interventions to mitigate these effects.
dc.identifier.citationMüdüroğlu Kırmızıbekmez, A., Önder, A., Özdemir, M. Y., Eryiğit, Ö. Y., & Yurdakoş, E. (2025). Is neurodegeneration accelerated? Investigating covıd-19’s impact on dementia via functional connectivity. Archives of Neuropsychiatry, 62(3), pp. 274-278. https://doi.org/10.29399/npa.29085
dc.identifier.doi10.29399/npa.29085
dc.identifier.endpage278
dc.identifier.issn1309-4866
dc.identifier.issue3
dc.identifier.pmidPMID: 40950821
dc.identifier.scopus2-s2.0-105014979091
dc.identifier.scopusqualityQ3
dc.identifier.startpage274
dc.identifier.urihttps://doi.org/10.29399/npa.29085
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1096
dc.identifier.volume62
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorYurdakoş, Ertan
dc.institutionauthorEryiğit, Önder Yüksel
dc.institutionauthorid0000-0002-3209-852X
dc.institutionauthorid0000-0002-7855-7779
dc.language.isoen
dc.publisherTurkish Neuropsychiatric Society
dc.relation.ispartofArchives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectDementia
dc.subjectElectroencephalography
dc.subjectFunctional Connectivity
dc.subjectNeurodegeneration
dc.titleIs neurodegeneration accelerated? Investigating covıd-19’s impact on dementia via functional connectivity
dc.title.alternativeNörodejenerasyon hızlanıyor mu? Covıd-19’un demans üzerindeki etkisini fonksiyonel bağlantısallık yoluyla incelemek
dc.typeArticle
dspace.entity.typePublication

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