Biomimetic management of orthodontic white spot lesions

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dc.authorid0000-0001-7371-1215
dc.authorid0000-0002-1206-2546
dc.authorid0000-0002-4553-2655
dc.authorid0000-0001-5918-3858
dc.contributor.authorTunalı, Esra
dc.contributor.authorKaraçay, Şeniz
dc.contributor.authorÖzen, Buğra
dc.contributor.authorAlbayrak, Önder
dc.date.accessioned2025-08-05T20:44:21Z
dc.date.available2025-08-05T20:44:21Z
dc.date.issued2025
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü, Pedodonti Ana Bilim Dalı
dc.description.abstractObjectives: white spot lesions (WSLs) may develop in patients with inadequate oral hygiene during orthodontic treatment. This study aimed to develop a natural remineralization agent by creating artificial WSLs in vitro. Materials/methods: WSLs were created in teeth with orthodontic buttons in vitro. The teeth were divided into the following groups: P11-4 (group 1), Nano-HA solution before sintering (group 2), Nano-HA solution after sintering (group 3), P11-4 and Nano-HA mixture before sintering (group 4), P11-4 and Nano-HA mixture after sintering (group 5), boron-containing Nano-HA mixture before sintering (group 6), boron-containing Nano-HA mixture after sintering (group 7), CPP-ACP (group 8), and artificial saliva (group 9). Measurements were taken before and after demineralization, and at the 7th, 14th, 21st, and 28th days of remineralization. Images were recorded using DIAGNOcam and VistaCamIX, area measurements were made using ImageJ, and SEM was used for remineralization assessment. Results: all groups except group 9 showed a reduction in the WSL area, with statistically significant results. SEM analysis revealed the lowest remineralization in groups 8 and 9, while the other groups exhibited more intense remineralization. Conclusions: the most successful groups for WSL remineralization were those containing pure Nano-HA (groups 2 and 3), with the other groups showing varying levels of remineralization.
dc.identifier.citationTunalı, E., Karaçay, Ş., Özen, B., & Albayrak, Ö. (2025). Biomimetic management of orthodontic white spot lesions. Journal of Materials Chemistry B, 13(33), https://doi.org/10.1039/d5tb00306g
dc.identifier.doi10.1039/d5tb00306g
dc.identifier.issn2050-750X
dc.identifier.issn2050-7518
dc.identifier.issue33
dc.identifier.pmidPMID: 40735869
dc.identifier.scopus2-s2.0-105013655613
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1039/d5tb00306g
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1067
dc.identifier.volume13
dc.identifier.wosWOS:001539096500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖzen, Buğra
dc.institutionauthorid0000-0002-4553-2655
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofJournal of Materials Chemistry B
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleBiomimetic management of orthodontic white spot lesions
dc.typeArticle
dspace.entity.typePublication

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