Circulating microRNAs as promising biomarkers in parkinson’s disease

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dc.authorid0000-0001-9910-8713
dc.authorid0000-0003-1608-9882
dc.authorid0009-0009-7894-3440
dc.authorid0000-0003-4927-6625
dc.authorid0000-0002-5468-8934
dc.authorid0000-0003-0557-951X
dc.authorid0009-0006-8402-2865
dc.authorid0000-0003-2908-8475
dc.contributor.authorKaya, İbrahim Alper
dc.contributor.authorDemircan, Berna
dc.contributor.authorÖzdilek, Fatma Betül
dc.contributor.authorBaran, Mustafa
dc.contributor.authorDoğan, Emine Sena
dc.contributor.authorKoç Ada, Saniye
dc.contributor.authorBursa, Muhammet Çağlar
dc.contributor.authorKaya Bursa, Aslı Pelin
dc.contributor.authorÖztekin, Zeynep
dc.contributor.authorGürvit, İbrahim Hakan
dc.date.accessioned2026-07-29T13:27:38Z
dc.date.available2026-07-29T13:27:38Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractOur study aims to examine possible Parkinson Disease (PD)-related circulating microRNAs (miRNA) and their potential roles and use cases in screening, diagnosis, and the disease progress in Turkish population. For this purpose, we selected 7 promising candidates namely miR-16–1, miR-24-3p, miR-30a, miR-30e, miR-34a, miR-34b, miR-331 from multiple studies and bioinformatic web tools. For our study, 51 PD patients with no other severe disease except for hypertension and 20 healthy matching controls were included. Serum samples were collected from venous blood and stored properly. RNA extraction, reverse transcription and real-time polymerase chain reaction (qPCR) for each pre-determined miRNA were applied to all samples with a strong normalization method to determine expression levels. Additionally, validated miR-24-3p target genes were intersected against publicly available CSF proteomics (PXD011216), PBMC transcriptomics (GSE22491), and serum metabolomics (MTBLS10958) datasets. miR-24-3p expression was also examined in two independent miRNA datasets (GSE269775; GSE16658). Statistical analyses were done using SPSS and Qiagen GeneGlobe webtools. Between PD and the control group, miR-24-3p serum levels were found increased 1.7 times (p = 0.0001). Among patients, miR-331 serum levels changed significantly with UPDRS scores (p = 0.027). Multi-omics analysis identified 21 differentially abundant miR-24-3p target proteins in PD CSF (81% downregulated), three cross-platform concordant targets, and five metabolically linked pathways. miR-24-3p levels may differ in different biological compartments in PD. In serum, miR-24-3p may provide significant value as a diagnostic biomarker with 80.4% sensitivity and 85% specificity. miR-331 might be a candidate for predicting the severity of the disease.
dc.identifier.citationKaya, İ. A., Demircan, B., Özdilek, F. B., Baran, M., Doğan, E. S., Koç Ada, S., Bursa, M. Ç., Kaya Bursa, A. P., Öztekin, Z., & Gürvit, İ. H. (2026). Circulating microRNAs as promising biomarkers in parkinson’s disease. Molecular Neurobiology, 63(1), pp. 1-15. https://doi.org/10.1007/s12035-026-06045-x
dc.identifier.doi10.1007/s12035-026-06045-x
dc.identifier.issn1559-1182
dc.identifier.issn0893-7648
dc.identifier.issue1
dc.identifier.pmidPMID: 42446817
dc.identifier.scopus2-s2.0-105044507520
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12035-026-06045-x
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1569
dc.identifier.volume63
dc.identifier.wosWOS:001820700100004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorDoğan, Emine Sena
dc.institutionauthorid0009-0009-7894-3440
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofMolecular Neurobiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMiR-24-3p
dc.subjectMiR-34b
dc.subjectMiR-331
dc.subjectExosomal MicroRNA
dc.subjectParkinson’s Disease
dc.subjectQrtpcr
dc.titleCirculating microRNAs as promising biomarkers in parkinson’s disease
dc.typeArticle
dspace.entity.typePublication

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