CYB5R4 gene methylation as a potential epigenetic marker for ovarian cancer

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dc.authorid0000-0002-4459-2939
dc.authorid0000-0002-0893-1251
dc.authorid0000-0003-4417-4005
dc.authorid0000-0001-7923-275X
dc.authorid0000-0002-5985-070X
dc.authorid0000-0001-6530-0942
dc.authorid0000-0001-6871-8519
dc.authorid0000-0002-8919-0482
dc.authorid0000-0001-8023-3223
dc.contributor.authorGönç, Ayşegül
dc.contributor.authorŞükrüoğlu Erdoğan, Özge
dc.contributor.authorKılıç Erciyas, Seda
dc.contributor.authorÇelik Demirbaş, Betül
dc.contributor.authorDinç, Ahmet
dc.contributor.authorPasin, Özge
dc.contributor.authorSaip, Pınar
dc.contributor.authorYazıcı, Hülya
dc.contributor.authorTunçer, Şeref Buğra
dc.date.accessioned2025-06-23T08:40:24Z
dc.date.available2025-06-23T08:40:24Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractBackground: Ovarian cancer (OC) is a significant health problem often diagnosed at an advanced stage due to the lack of early symptoms and effective screening methods. This study aimed to explore the role of CYB5R4 gene methylation as a potential biomarker for ovarian cancer. Methods: DNA isolation was performed in the blood samples of 387 ovarian cancer patients, 50 individuals with benign ovarian diseases, and 100 healthy controls. The CYB5R4 gene methylation status was evaluated using the Methyl-Specific Restriction Enzymes (MSREs) technique and methylation levels were compared between the groups. Results: Ovarian cancer patients exhibited the highest mean methylation percentage (9.45%) and median (6.23%), followed by healthy controls with a mean of 9.14% and a median value of 4.47%. Statistical analysis showed significant differences in methylation levels (P=.041), suggesting that CYB5R4 methylation may be associated with ovarian cancer progression. Conclusion: The CYB5R4 gene methylation may serve as a potential biomarker for ovarian cancer, particularly in distinguishing between malignant and benign conditions. Further research is needed to validate these findings and explore the clinical utility of CYB5R4 methylation in ovarian cancer management.
dc.description.sponsorshipThis research was funded by Istanbul University Scientific Research Projects Coordination, grant number TYL-2021-38000, and TOA-2020-35780. Bu araştırma İstanbul Üniversitesi Bilimsel Araştırma Projeleri Koordinasyonu tarafından TYL-2021-38000 ve TOA-2020-35780 numaralı hibe ile finanse edilmiştir.
dc.identifier.citationGönç, A., Şükrüoğlu Erdoğan, Ö., Kılıç Erciyas, S., Çelik Demirbaş, B., Dinç, A., Pasin, Ö., Saip, P., Yazıcı, H., & Tunçer, Ş. B. (2025). CYB5R4 gene methylation as a potential epigenetic marker for ovarian cancer. Clinical Medicine Insights: Oncology, 19, pp. 1-7. https://doi.org/10.1177/11795549251340531
dc.identifier.doi10.1177/11795549251340531
dc.identifier.endpage7
dc.identifier.issn1179-5549
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1177/11795549251340531
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1005
dc.identifier.volume19
dc.identifier.wosWOS:001512295100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorYazıcı, Hülya
dc.institutionauthorid0000-0002-8919-0482
dc.language.isoen
dc.publisherSAGE Publications
dc.relation.ispartofClinical Medicine Insights: Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOvarian Cancer
dc.subjectCYB5R4 Gene
dc.subjectDNA Methylation
dc.subjectBiomarker
dc.subjectEarly Detection
dc.titleCYB5R4 gene methylation as a potential epigenetic marker for ovarian cancer
dc.typeArticle
dspace.entity.typePublication

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